PMID: 9535247Apr 16, 1998Paper

Diphtheria, tetanus and whole cell pertussis vaccine combined with hepatitis B vaccines: a comparison of two doses (10 microg and 5 microg)

The Pediatric Infectious Disease Journal
H H ChiuC Y Lee

Abstract

A combined diphtheria-tetanus-whole cell pertussis-hepatitis B (DTPwHB) vaccine might facilitate the achievement of universal vaccination of infants against hepatitis B. A double blind, randomized, two-armed, single center study was undertaken to evaluate the immunogenicity and reactogenicity of combined tetravalent DTPwHB vaccine, with two dosages of hepatitis B component (10 microg and 5 microg). The combined vaccine was tested in the context of a simplified vaccination schedule at 1.5, 3.5 and 6 months of age, to 120 healthy infants born to hepatitis B surface antigen-negative mothers after priming with one dose of hepatitis B vaccine (10 microg) at birth. Antibodies to each antigenic component were measured from blood samples collected immediately after birth, pre- and postvaccination blood samples. The reactogenicity profiles were similar in the two groups. No serious adverse events were reported. One month after completion of the four-dose vaccination schedule, all subjects except one in Group 1 (10 microg) had protective titers of anti-HBs (10 mIU/ml). At this time the geometric mean titer in Group 1 (10 microg) was higher than that observed in Group 2 (5 microg), 696 vs. 488 mIU/ml (P = 0.19). One month after three dose...Continue Reading

Citations

Nov 27, 2002·Vaccine·Supamit ChunsuttiwatMonthakarn O-Prasertsawat
Apr 30, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Stella RiedemannHans L Bock
Mar 20, 1999·Current Opinion in Pediatrics·S Choo, A Finn
Mar 21, 2008·Expert Opinion on Biological Therapy·Roman Prymula, Stanislav Plisek
Apr 13, 2000·Pediatric Clinics of North America·M E Pichichero
Jul 4, 2003·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Javier ArísteguiHans L Bock
Jul 13, 2012·The Cochrane Database of Systematic Reviews·Greg J IrvingDaniel Pope

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