May 30, 2009

Diploidy, population structure, and the evolution of recombination

The American Naturalist
D Roze


In diploids, sex affects genetic variation through segregation and recombination. Several recent models on the advantage of recombination have focused on the effect of interaction between selection and drift in finite or structured populations; however, these models considered haploid organisms. In this article, I present a three-locus model of the evolution of recombination in structured diploid populations, including dominance and epistatic effects among alleles. This model shows that dominance generates a selective force against recombination due to the fact that recombination reduces correlations in homozygosity that are generated by population structure. This result is confirmed by multilocus simulations (representing deleterious mutations occurring over a whole genome), showing that when mutations are sufficiently recessive, the population evolves to zero recombination. In the presence of epistasis, the same effect of recombination on correlations in homozygosity generates an advantage for recombination under negative dominance by dominance epistasis (e(d x d)). Additive by additive epistasis (e(a x a)) favors recombination when it is negative and sufficiently weak, while additive by dominance epistasis has less effect. S...Continue Reading

  • References
  • Citations26


  • We're still populating references for this paper, please check back later.
  • References
  • Citations26

Mentioned in this Paper

Recombination, Genetic
Deleterious Mutation
Deviation, Epistatic
Diploid Cell
Genes, Dominant
Biological Evolution

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Bone Marrow Neoplasms

Bone Marrow Neoplasms are cancers that occur in the bone marrow. Discover the latest research on Bone Marrow Neoplasms here.

IGA Glomerulonephritis

IgA glomerulonephritis is a chronic form of glomerulonephritis characterized by deposits of predominantly Iimmunoglobin A in the mesangial area. Discover the latest research on IgA glomerulonephritis here.

Cryogenic Electron Microscopy

Cryogenic electron microscopy (Cryo-EM) allows the determination of biological macromolecules and their assemblies at a near-atomic resolution. Here is the latest research.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

LRRK2 & Immunity During Infection

Mutations in the LRRK2 gene are a risk-factor for developing Parkinson’s disease. However, LRRK2 has been shown to function as a central regulator of vesicular trafficking, infection, immunity, and inflammation. Here is the latest research on the role of this kinase on immunity during infection.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Meningococcal Myelitis

Meningococcal myelitis is characterized by inflammation and myelin damage to the meninges and spinal cord. Discover the latest research on meningococcal myelitis here.

Alzheimer's Disease: MS4A

Variants within membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease by recent genome-wide association studies. Here is the latest research.