Diprenorphine as a stimulus in drug discrimination learning

Pharmacology, Biochemistry, and Behavior
S T Smurthwaite, A L Riley


Using the conditioned taste aversion baseline of drug discrimination learning, animals were trained to discriminate diprenorphine from distilled water. In subsequent generalization tests, the opiate antagonists naltrexone and naloxone and the mixed opiate agonist/antagonist nalorphine substituted for the diprenorphine stimulus in a dose-dependent manner, while the opiate agonist morphine and the nonopiate pentobarbital failed to substitute even at the highest doses tested. That a range of opiate antagonists substituted for the diprenorphine stimulus (and an opiate agonist and a nonopiate failed to substitute) suggest that diprenorphine's antagonist properties may mediate the discrimination, presumably by blocking endogenous opiate activity. The ability of these drugs to substitute for the diprenorphine stimulus may also be a function of this receptor activity. The differences in the specific generalization patterns reported in the present assessment and those of earlier reports were discussed.


Jan 1, 1979·Psychopharmacology·L G Frey, J C Winter
Nov 15, 1977·Psychopharmacology·I D Hirschhorn
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·G W StevensonA L Riley
Jan 1, 1992·Pharmacology, Biochemistry, and Behavior·S T SmurthwaiteA L Riley
Aug 1, 1991·Pharmacology, Biochemistry, and Behavior·F Woudenberg, T H Hijzen
Jun 1, 1982·Naunyn-Schmiedeberg's Archives of Pharmacology·J MagnanH W Kosterlitz
Aug 1, 1981·British Journal of Pharmacology·H W KosterlitzL E Robson
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·K J ChangP Cuatrecasas
Jan 1, 1982·Psychopharmacology·R B Carter, J D Leander
Dec 1, 1982·Pharmacology, Biochemistry, and Behavior·K W LockeS G Holtzman
Apr 29, 1998·Trends in Pharmacological Sciences·S D BryantL H Lazarus
Nov 1, 1991·Behavioural Pharmacology·I. Lucki, J.M. Marcoccia


Nov 1, 1993·Pharmacology, Biochemistry, and Behavior·S Pournaghash, A L Riley
Jul 1, 1994·Pharmacology, Biochemistry, and Behavior·S T Smurthwaite, A L Riley
Nov 1, 1993·Peptides·G A OlsonA J Kastin

Related Concepts

Chloride Ion Level
Conditioning (Psychology)
Discrimination Learning
Dose-Response Relationship, Drug
Generalization (Psychology)
Morphine Sulfate (2: 1), Pentahydrate
Nalorphine, L-tartrate (1: 1)

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.