Dipyrithione inhibits lipopolysaccharide-induced iNOS and COX-2 up-regulation in macrophages and protects against endotoxic shock in mice

FEBS Letters
Ziwen LiuZ Yin

Abstract

Dipyrithione (PTS2) possesses anti-bacterial and anti-fungal activity. In the present study, we found that PTS2 dose-dependently inhibited the LPS-induced up-regulation of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein level in RAW264.7 cells. RT-PCR experiments showed that PTS2 suppressed LPS-induced iNOS but not COX-2 expression at the mRNA level. As expected, PTS2 prevented NO secretion in RAW264.7 cells. Furthermore, PTS2 administration significantly decreased LPS-induced mortality in mice. Mechanistically, PTS2 decreased expression and phosphorylation of STAT1, but did not interfere with the MAPK and NF-kappaB pathways. In conclusion, PTS2 protects mice against endotoxic shock and inhibits LPS-induced production of pro-inflammatory mediators, suggesting that PTS2 could play an anti-inflammatory role in response to LPS.

References

Sep 21, 1991·Lancet·M P GlauserJ Cohen
May 1, 1994·The Journal of Clinical Investigation·D SalveminiP Needleman
Apr 1, 1995·Clinical Microbiology Reviews·J C Hurley
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D SalveminiP Needleman
Jan 1, 1994·Annual Review of Immunology·P A Baeuerle, T Henkel
Jan 1, 1997·Annual Review of Immunology·J MacMickingC Nathan
Jun 1, 1997·The International Journal of Biochemistry & Cell Biology·P J Barnes
May 23, 1998·Annual Review of Pharmacology and Toxicology·J R VaneR M Botting
Mar 4, 1999·The EMBO Journal·V AdlerZ Ronai
Aug 18, 1999·Journal of the Royal Society of Medicine·S Moncada
Feb 15, 2001·American Journal of Physiology. Cell Physiology·E D Chan, D W Riches
Jan 31, 2002·Annual Review of Medicine·Marco E Turini, Raymond N DuBois
Feb 9, 2002·Journal of Pharmaceutical Sciences·Gouri G Malhotra, Joel L Zatz
Jan 23, 2003·International Immunopharmacology·Víctor Manuel VíctorMónica De la Fuente
Feb 15, 2003·Trends in Cardiovascular Medicine·Roberto BolliYu-Ting Xuan
May 10, 2003·Journal of Molecular and Cellular Cardiology·Yu-Ting XuanRoberto Bolli
Aug 2, 2003·International Immunopharmacology·Soichi NoguchiTakafumi Kudo
Mar 5, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sang Hyun KimRaghubir P Sharma
Nov 6, 2004·Journal of Chromatography. a·Caren Anja DooseBernd Jastorff
May 11, 2005·Neuroscience Letters·C MarchiniE Fioretti
Aug 17, 2005·Current Drug Targets. Inflammation and Allergy·Riku KorhonenEeva Moilanen
Dec 24, 2005·Shock·Daniel G Remick, Peter A Ward
Nov 2, 2006·Biological & Pharmaceutical Bulletin·Jian-You GuoTing-Liang Jiang
Apr 7, 2007·Current Opinion in Rheumatology·Zoltán Szekanecz, Alisa E Koch
Jul 7, 2007·Sub-cellular Biochemistry·K D Rainsford

❮ Previous
Next ❯

Citations

Apr 8, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Cui HanZhimin Yin
Apr 3, 2014·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xiaolong PanLei Lan
Feb 9, 2016·Journal of Agricultural and Food Chemistry·Ching-Peng ChiuYang-Chang Wu
Oct 5, 2010·Pulmonary Pharmacology & Therapeutics·Huang HuangLan Luo
Aug 10, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Meihua JinHyeun Wook Chang
Sep 26, 2014·Scientific Reports·Fengping ChenXili Liu
Aug 19, 2015·Biochemical and Biophysical Research Communications·Shengnan WangYumei Fan
Jan 30, 2010·Immunopharmacology and Immunotoxicology·Choi Yi LiewDaud Ahmad Israf
Jun 5, 2016·Toxicology and Applied Pharmacology·Weifeng LiHuan Yao
Apr 15, 2017·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Lei ShenZhimin Yin

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here