PMID: 15362592Sep 15, 2004Paper

Dipyrone overdose

Journal of Toxicology. Clinical Toxicology
Yedidia Bentur, Omri Cohen

Abstract

Dipyrone is a pyrazolone derivative used as an analgesic and antipyretic. Agranulocytosis, dipyrone's most serious and potentially fatal adverse effect, has led to its withdrawal in several countries. However, agranulocytosis is subject to geographical variability, ratio with at risks ranging from 0.8-23.7. In many countries dipyrone is still widely used in adults and children and even as an over-the-counter (OTC) preparation. Information on the effects of dipyrone overdose is scanty. To determine the demographic and clinical characteristics of dipyrone overdose. Retrospective review of prospectively collected poison center data on acute exposure to dipyrone over a three-year period. The data were subjected to descriptive analysis. Mann-Whitney test and Chi-square analysis were performed where relevant. A total of 243 records met the inclusion and exclusion criteria. Median age was 17y (4m-83y), median amount 5 g (250 mg-45 g), and median time to consultation was 2 h (5 min-48 h). Toxic events (49) occurred in 39 (16%) patients; 57% of these were gastrointestinal and all were mild. Time to consultation was longer in the symptomatic patients (4 h vs. 1.5 h, respectively, p=0.001) and in children (8 h vs. 3.5 h in adults). Suicid...Continue Reading

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Citations

Dec 12, 2007·Journal of Medical Toxicology : Official Journal of the American College of Medical Toxicology·Mathias B Forrester
Mar 18, 2008·Pathologie-biologie·C Garcia-HejlL Brinquin
Dec 18, 2013·Basic & Clinical Pharmacology & Toxicology·Ophir LavonYedidia Bentur
Feb 7, 2006·Free Radical Biology & Medicine·David CostaEduarda Fernandes
Apr 1, 2011·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·G MariappanDeepak Kumar
Jun 6, 2006·Clinical Toxicology : the Official Journal of the American Academy of Clinical Toxicology and European Association of Poisons Centres and Clinical Toxicologists·Yedidia BenturEran Kozer
Jun 30, 2006·Redox Report : Communications in Free Radical Research·David CostaEduarda Fernandes
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Jul 24, 2008·Redox Report : Communications in Free Radical Research·David CostaEduarda Fernandes
Jul 5, 2006·Biological & Pharmaceutical Bulletin·Shirui MaoDianzhou Bi

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