Direct 4D reconstruction of parametric images incorporating anato-functional joint entropy.

Physics in Medicine and Biology
Jing TangArman Rahmim

Abstract

We developed an anatomy-guided 4D closed-form algorithm to directly reconstruct parametric images from projection data for (nearly) irreversible tracers. Conventional methods consist of individually reconstructing 2D/3D PET data, followed by graphical analysis on the sequence of reconstructed image frames. The proposed direct reconstruction approach maintains the simplicity and accuracy of the expectation-maximization (EM) algorithm by extending the system matrix to include the relation between the parametric images and the measured data. A closed-form solution was achieved using a different hidden complete-data formulation within the EM framework. Furthermore, the proposed method was extended to maximum a posterior reconstruction via incorporation of MR image information, taking the joint entropy between MR and parametric PET features as the prior. Using realistic simulated noisy [(11)C]-naltrindole PET and MR brain images/data, the quantitative performance of the proposed methods was investigated. Significant improvements in terms of noise versus bias performance were demonstrated when performing direct parametric reconstruction, and additionally upon extending the algorithm to its Bayesian counterpart using the MR-PET joint ...Continue Reading

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Citations

Jul 19, 2012·Physics in Medicine and Biology·Lijun LuArman Rahmim
Jan 8, 2014·Theranostics·Guobao Wang, Jinyi Qi
May 31, 2013·Medical Physics·Arman RahmimVesna Sossi
Mar 10, 2016·PET Clinics·Charalampos TsoumpasGeorge Loudos
Mar 10, 2016·PET Clinics·Kjell ErlandssonBrian F Hutton
Feb 24, 2015·IEEE Transactions on Medical Imaging· Xiaoyin Cheng Kuangyu Shi
Jan 27, 2015·IEEE Transactions on Medical Imaging·Guanglei ZhangJing Bai
Nov 13, 2013·IEEE Transactions on Medical Imaging·Yanguang LinRichard Leahy
Aug 16, 2012·IEEE Transactions on Medical Imaging·Guobao Wang, Jinyi Qi
May 3, 2015·IEEE Transactions on Medical Imaging·Rebekka LoebSibylle I Ziegler
Jul 5, 2016·The British Journal of Radiology·Jorge Cabello, Sibylle I Ziegler
Oct 2, 2013·Physics in Medicine and Biology·Nicolas A KarakatsanisArman Rahmim
Oct 2, 2013·Physics in Medicine and Biology·Nicolas A KarakatsanisArman Rahmim
Oct 30, 2015·Physics in Medicine and Biology·Roger N GunnJulie C Price
Jun 27, 2015·Biomedical Optics Express·Guanglei ZhangJianwen Luo
Oct 29, 2015·Physics in Medicine and Biology·Nicolas A KarakatsanisArman Rahmim
Dec 6, 2014·Physics in Medicine and Biology·Jing Tang, Arman Rahmim
Nov 2, 2014·Physics in Medicine and Biology·Andrew J Reader, Jeroen Verhaeghe
Sep 14, 2013·Physics in Medicine and Biology·Arman Rahmim, Jing Tang
Aug 17, 2019·Frontiers in Neuroscience·Yuankai Zhu, Xiaohua Zhu
May 27, 2016·Physics in Medicine and Biology·Philip Novosad, Andrew J Reader
Oct 1, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Arman RahmimRichard L Wahl

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