Direct access of drugs to the human brain after intranasal drug administration?

Neurology
Paul MerkusFrans W H M Merkus

Abstract

It has been suggested that intranasal (IN) drug delivery could be used to administer drugs directly to the brain, bypassing the blood-brain barrier. Conclusive evidence of this proposed route of drug transport has not been observed by IN-IV comparison. In eight neurosurgery patients with a CSF drain, the uptake in CSF and plasma after IN and IV drug administration was compared. No evidence of direct access of the drugs from the nose to the CSF was found.

Citations

Jun 8, 2007·Pharmaceutical Research·William M Pardridge
May 17, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Joke P M in 't VeenFrans W H M Merkus
Jun 11, 2009·The Journal of Pharmacology and Experimental Therapeutics·Leah R HansonS Scott Panter
Feb 18, 2005·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·William M Pardridge
Jul 28, 2012·Therapeutic Delivery·Catherine CampbellAnthony W Fox
Dec 19, 2013·Neurotoxicity Research·Hanane KadarRita Raisman-Vozari
Sep 27, 2008·Expert Opinion on Drug Delivery·Hongbing WuXinguo Jiang
Mar 17, 2007·Journal of Drug Targeting·Kenji YamadaShusei Ito
Jun 6, 2014·Drug Delivery·Amrish KumarSunil Kumar Jain
Oct 8, 2009·Journal of Drug Targeting·Sandra R Alcalá-BarrazaLinda K McLoon
Mar 25, 2011·Journal of Drug Targeting·R Jayachandra BabuMandip Singh
Oct 30, 2004·Journal of Drug Targeting·Eduard N LernerGregory R Stewart
Dec 12, 2003·Journal of Drug Targeting·Mascha P Van den BergFrans W H M Merkus
Jul 25, 2015·Expert Opinion on Drug Delivery·Yongjun JiangXinfeng Liu
Dec 1, 2009·Neurosurgery Clinics of North America·Charles W KanalyJohn H Sampson
Jun 27, 2009·International Journal of Pharmaceutics·Alpesh MistryLisbeth Illum
Aug 30, 2012·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·William M Pardridge
Mar 15, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Per G DjupeslandJohn C Messina
Jan 3, 2007·Drug Discovery Today·William M Pardridge
Mar 24, 2016·Artificial Cells, Nanomedicine, and Biotechnology·Amrish Kumar, Sunil Kumar Jain
Sep 12, 2012·Peptides·Jun YangJing-Cheng Wang
Jun 5, 2003·Expert Opinion on Biological Therapy·Julie D Suman
Jun 5, 2015·Translational Stroke Research·Vasileios-Arsenios LioutasVera Novak
Jan 29, 2011·Bioorganic & Medicinal Chemistry·Cécile D CrosJoanne T Blanchfield
Feb 26, 2004·The Journal of Pharmacy and Pharmacology·Lisbeth Illum
May 23, 2017·Therapeutic Delivery·Aroonsri PripremNutjaree Prateepawanit Johns
Mar 19, 2015·American Journal of Rhinology & Allergy·Marcel Menon Miyake, Benjamin S Bleier
Aug 19, 2018·The European Journal of Neuroscience·Enrico Bagnoli, Una FitzGerald
Jun 30, 2006·Expert Opinion on Pharmacotherapy·Roger S McIntyreSidney H Kennedy
Jan 31, 2020·Frontiers in Aging Neuroscience·William M Pardridge
May 3, 2007·Drugs in R&D·Frans W H M Merkus, Mascha P van den Berg
Jan 20, 2016·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Anne C BaakmanGeert J Groeneveld
Jun 2, 2017·Molecular Cancer Therapeutics·Amanda R KingW Mark Saltzman
Nov 20, 2020·Pharmaceuticals·William M Pardridge
Feb 6, 2021·International Journal of Pharmaceutics·Manisha ChoudhariSunil Kumar Dubey
Oct 17, 2017·ACS Chemical Neuroscience·Genevieve C Van de BittnerJacob M Hooker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.