Direct-acting antiviral treatment in real world patients with hepatitis C not associated with psychiatric side effects: a prospective observational study

BMC Psychiatry
Isak SundbergJanet L Cunningham

Abstract

Treatment of Hepatitis C virus (HCV) infection has evolved from interferon (IFN)-based treatments to direct-acting antivirals (DAAs). Patients with HCV have an elevated psychiatric morbidity (including substance abuse) and patients with such comorbidity have often been excluded from treatment with IFN. To date, little is known about psychiatric adverse effects of DAA-based regimens. We therefore aimed to study the psychiatric side effects of new IFN-free treatment for HCV (including depressive symptoms and sleep) in real world patients also including those with a history of psychiatric diagnosis, substance abuse or drug dependence. Consecutive patients were monitored during treatment with three of the latest DAA agents (sofosbuvir, simeprevir and daclatasvir). Repeated expert psychiatric assessments from baseline to 12 weeks post-treatment were performed with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I) clinical version and the self-report versions of the Montgomery Åsberg Depression Rating Scale (MADRS-S) and the Pittsburgh Sleep Quality Index (PSQI). Friedman's test was performed to calculate differences in the MADRS-S and PSQI over time. In a post-hoc analysis Wilcoxon's test was used to compare bas...Continue Reading

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Citations

Apr 7, 2020·Harvard Review of Psychiatry·Gustavo C MedeirosScott R Beach
Sep 26, 2020·BMC Infectious Diseases·Marta TorrensEberhard Schatz
Sep 26, 2019·General Psychiatry·Carmen Maura Carrillo de Albornoz CalahorroLuis Gutierrez Rojas
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Jun 20, 2020·European Journal of Gastroenterology & Hepatology·Amal Tohamy Abdel MoezAmira Mahmoud Al Balakosy
Jul 18, 2021·The Lancet. Gastroenterology & Hepatology·Thomas MarjotMatthew J Armstrong

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Methods Mentioned

BETA
biopsy

Software Mentioned

AUDIT
DUDIT
Statistical Package for the Social Sciences

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