Direct-Acting Antiviral Treatment of Patients with Hepatitis C Resolves Serologic and Histopathologic Features of Autoimmune Hepatitis

Hepatology Communications
Camila C SimoesHeather L Stevenson

Abstract

Patients with hepatitis C virus (HCV) often have elevated serum markers and histologic features of autoimmune hepatitis (AIH). We evaluated an HCV-positive (HCV+) study group that had elevated serum markers of AIH before starting direct-acting antiviral (DAA) therapy (n = 21) and compared them to an HCV+ control group that did not have laboratory studies suggesting AIH (n = 21). Several patients in the study (17/21) and control (11/21) groups had liver biopsies before DAA treatment, and many were biopsied due to elevated serum markers of AIH. Evaluation of pre-DAA treatment liver biopsies showed histologic features suggestive of AIH in 64.7% (11/17) of the study group and 45.5% (5/11) of the control group. Patients who were HCV+ with elevated serum markers of AIH had significantly increased hepatitis activity (P < 0.001) and slightly increased fibrosis stages (P = 0.039) in their pretreatment liver biopsies compared to controls. We hypothesized that the elevated serum markers and histologic features of AIH would resolve following DAA treatment. Serum markers of AIH in the study group began decreasing by 6 months posttreatment, and 52.4% (11/21) had complete resolution. Alanine aminotransferase levels significantly decreased int...Continue Reading

References

Sep 1, 1981·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R G KnodellJ Wollman
Dec 1, 1995·The American Journal of Surgical Pathology·K P Batts, J Ludwig
Jan 1, 1994·Journal of Medical Virology·B M McFarlaneI G McFarlane
Jun 1, 1995·Journal of Hepatology·K IshakR N MacSween
Apr 1, 1993·Digestive Diseases and Sciences·M W FriedA M Di Bisceglie
Sep 26, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F CassaniF B Bianchi
Apr 30, 2004·Srpski arhiv za celokupno lekarstvo·Slanjana PavićNeda Svirtlih
Jun 10, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elke M HennesUNKNOWN International Autoimmune Hepatitis Group
Apr 17, 2009·The Journal of Rheumatology·Manuel Ramos-CasalsUNKNOWN HISPAMEC Study Group
Jun 1, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Michael P MannsUNKNOWN American Association for the Study of Liver Diseases
Nov 26, 2010·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·D Lavanchy
May 11, 2011·Hepatology International·Raj VuppalanchiUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN)
Sep 19, 2012·Clinical & Developmental Immunology·Takashi Himoto, Tsutomu Masaki
Nov 3, 2012·International Journal of General Medicine·Marino ParoliDaniele Accapezzato
Jan 1, 2014·World Journal of Gastroenterology : WJG·Vincenza Calvaruso, Antonio Craxì
Jun 24, 2014·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Laura GragnaniAnna Linda Zignego
Dec 10, 2014·The Lancet Infectious Diseases·Avina Sarna, Samiran Panda
Jun 9, 2015·World Journal of Hepatology·Janaína Luz Narciso-Schiavon, Leonardo de Lucca Schiavon
May 18, 2016·World Journal of Hepatology·Farhad SahebjamSamuel H Sigal
Aug 16, 2016·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·S LaniniG Ippolito
Jan 21, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Dana BalitzerSanjay Kakar

❮ Previous
Next ❯

Citations

Dec 10, 2020·Clinical and Molecular Hepatology·Atsumasa Komori

❮ Previous
Next ❯

Methods Mentioned

BETA
SMA
biopsy
biopsies
ELISA

Software Mentioned

SigmaPlot

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.