Direct-acting antivirals for children and adolescents with chronic hepatitis C

The Lancet Child & Adolescent Health
Giuseppe IndolfiMassimo Resti

Abstract

In 2017, the US Food and Drug Administration (FDA) and European Medicines Agency (EMA) approved the fixed-dose direct-acting antiviral (DAA) combination sofosbuvir and ledipasvir and the combination sofosbuvir plus ribavirin for the treatment of adolescents (aged 12-17 years) with chronic hepatitis C. Preliminary results on the use of DAAs in paediatric patients are available for the fixed-dose combination sofosbuvir and ledipasvir in children aged 6-17 years for genotype 1 or 4 infection; for combination sofosbuvir plus ribavirin for adolescents aged 12-17 years for genotype 2 or 3 infection; for the fixed-dose combination ombitasvir, paritaprevir, and ritonavir with or without dasabuvir and with or without ribavirin for adolescents aged 12-17 years with genotype 1 or 4 infection; and for the combination of sofosbuvir plus daclatasvir for children with genotype 4 infection. All the results available indicated positive efficacy and favourable safety profiles of the different combinations of DAAs. With the approval of the new drugs, indications for treatment of children with chronic hepatitis C have changed. DAA therapy is recommended for all adolescents aged 12-17 years with chronic hepatitis C virus infection independent of tr...Continue Reading

Associated Clinical Trials

Citations

Sep 15, 2018·Journal of Pediatric Gastroenterology and Nutrition·Hanaa El-KaraksySawsan Okasha
Jul 25, 2019·Journal of Pediatric Gastroenterology and Nutrition·Daniele SerrantiGiuseppe Indolfi
Feb 7, 2020·Clinical and Experimental Pediatrics·Suk-Jin Hong, Byung-Ho Choe
Apr 30, 2020·Journal of Viral Hepatitis·Itzíar CarrascoUNKNOWN the Pediatric National AIDS Research Network of Spain (CoRISpe) integrated in the Translational Research Network in Pediatri
Oct 12, 2019·Journal of the Pediatric Infectious Diseases Society·Neil Dominic FernandesPhilip Fragassi
Nov 10, 2018·Hepatology Communications·Giuseppe Indolfi, Silvia Ricci
Jun 5, 2020·The Pediatric Infectious Disease Journal·Camila Bellettini HirschHeloisa Helena de Sousa Marques
Aug 19, 2020·Journal of Pediatric Gastroenterology and Nutrition·Daniele SerrantiGiuseppe Indolfi
Oct 6, 2019·Arab Journal of Gastroenterology : the Official Publication of the Pan-Arab Association of Gastroenterology·Mortada El-Shabrawi, Fetouh Hassanin
Feb 27, 2021·Journal of Pediatric Gastroenterology and Nutrition·Vasiliki MelikokiVassiliki Papaevangelou
Jul 31, 2021·The American Journal of Gastroenterology·Jie LiMindie H Nguyen
Aug 3, 2021·Expert Review of Gastroenterology & Hepatology·Chiara RubinoGiuseppe Indolfi

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