Direct-Acting Antivirals in Kidney Transplant Patients: Successful Hepatitis C Treatment and Short-Term Reduction in Urinary Protein/Creatinine Ratios

Pathogens & Immunity
Michael R GoetschRicardo A Franco

Abstract

The role of Hepatitis C Virus (HCV) clearance in kidney graft survival is unknown. We examined short-term trends of protein/creatinine (P/C) ratios in HCV-infected kidney transplant recipients treated with direct-acting antivirals (DAAs). This is a retrospective study of 19 kidney transplant patients with HCV infection treated with DAAs at the University of Alabama at Birmingham between January 2013 and June 2016. Markers of glomerular damage were assessed using average urinary protein/creatinine (P/C) ratios measured pretreatment and posttreatment. Treatment efficacy was defined as sustained virologic response at 12 weeks post-HCV treatment (SVR12). The median age of the 19 patients included was 59 years (Q1 = 58, Q3 = 64). Of these patients, 68% were African American, 32% were White and 63% were male. The median time between kidney transplant and initiation of DAA therapy was 2.25 years (Q1 = 0.79, Q3 = 3.79). Posttreatment P/C ratios (median = 0.127, Q1=0.090, Q3 = 0.220) were significantly lower (P = 0.01) than pretreatment ratios (median = 0.168, Q1 = 0.118, Q3 = 0.385). P/C ratios decreased in 14 of 19 patients (74%) with a median change of -0.072 (median percent change = -40%). Posttreatment estimated glomerular filtrati...Continue Reading

Citations

Oct 26, 2018·Clinical and Molecular Hepatology·Aiman ObedAnwar Jarrad
Jun 3, 2020·Medicine·Matt DriedgerCurtis Cooper
May 8, 2018·Journal of Clinical Pharmacy and Therapeutics·T MedeirosJ R Almeida
Apr 26, 2018·Hemodialysis International·Yuvaram N V ReddyJean M Francis
Mar 30, 2021·American Journal of Physiology. Renal Physiology·Lisa M CurtisAnupam Agarwal

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BETA
biopsy
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SAS

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