Direct action of capsaicin in brown adipogenesis and activation of brown adipocytes

Cell Biochemistry and Function
Ryosuke KidaMasayuki Funaba

Abstract

The ingestion of capsaicin, the principle pungent component of red and chili peppers, induces thermogenesis, in part, through the activation of brown adipocytes expressing genes related to mitochondrial biogenesis and uncoupling such as peroxisome proliferator-activated receptor (Ppar) γ coactivator-1α (Pgc-1α) and uncoupling protein 1 (Ucp1). Capsaicin has been suggested to induce the activation of brown adipocytes, which is mediated by the stimulation of sympathetic nerves. However, capsaicin may directly affect the differentiation of brown preadipocytes, brown adipocyte function, or both, through its significant absorption. We herein demonstrated that Trpv1, a capsaicin receptor, is expressed in brown adipose tissue, and that its expression level is increased during the differentiation of HB2 brown preadipocytes. Furthermore, capsaicin induced calcium influx in brown preadipocytes. A treatment with capsaicin in the early stage of brown adipogenesis did not affect lipid accumulation or the expression levels of Fabp4 (a gene expressed in mature adipocytes), Pparγ2 (a master regulator of adipogenesis) or brown adipocyte-selective genes. In contrast, a treatment with capsaicin in the late stage of brown adipogenesis slightly inc...Continue Reading

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Citations

Sep 10, 2016·Biochemical and Biophysical Research Communications·Osamu HashimotoMasayuki Funaba
Dec 22, 2016·Critical Reviews in Food Science and Nutrition·Csaba ZsiborásMargit Solymár
Aug 3, 2018·Biological & Pharmaceutical Bulletin·Kunitoshi UchidaMakoto Tominaga
Nov 23, 2017·Photochemistry and Photobiology·Michael R Hamblin
Dec 17, 2016·Nutrition & Metabolism·Yusra AzharSrujana Rayalam
Aug 16, 2018·Frontiers in Endocrinology·Stewart ChristieAmanda J Page
Sep 8, 2017·Biological Reviews of the Cambridge Philosophical Society·Phillipa K BealeBen D Moore
Mar 25, 2017·Journal of Physiology and Biochemistry·Virginia MelaVincenzo Di Marzo
Mar 19, 2019·The Journal of Veterinary Medical Science·Kazunari SekiyamaOsamu Hashimoto
Jun 29, 2017·The Journal of Physiological Sciences : JPS·Kunitoshi UchidaYusaku Iwasaki
Nov 10, 2018·Cell Biochemistry and Function·Mika SuzukiMasayuki Funaba
Feb 23, 2021·Frontiers in Cellular Neuroscience·Yaroslav M Shuba
Jun 26, 2021·Advances in Nutrition·Danielle L ÁvilaJacqueline I Alvarez-Leite
Jul 2, 2021·Biochemical and Biophysical Research Communications·Zhicheng DiaoMasayuki Funaba
Jul 13, 2021·Frontiers in Cell and Developmental Biology·Wuping SunTao Zhu
Jul 6, 2021·Phytotherapy Research : PTR·Dharmani Devi MuruganPooi-Fong Wong

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