Direct and indirect evidences of BDNF and NGF as key modulators in depression: role of antidepressants treatment

The International Journal of Neuroscience
Amal C Mondal, Mahino Fatima

Abstract

Depression is one of the most prevalent, recurrent and life-threatening mental illnesses. However, the precise mechanism underlying the disorder is not yet clearly understood. It is therefore, essential to identify the novel biomarkers which may help in the development of effective treatment. In this milieu, the profile of the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) were considered as biomarkers in the light of pathophysiology of depression and its treatment. Previously, we have reported that BDNF level in the postmortem brain of suicide victims was significantly lower than those of normal controls. We also found decreased BDNF levels in the specific brain regions of the learned helplessness model of depression in rat, and was found to increase normal level following chronic fluoxetine hydrochloride treatment. NGF is another important member of neurotrophin, which is dysregulated in the pathophysiology of depression in some models of peripheral nerve damage and stress. The results shown evidences of the effect of antidepressants on modulating depression via the NGF in preclinical and clinical models of depression, but conflicted, therefore make it currently difficult to affirm the therapeutic role...Continue Reading

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Citations

Jan 22, 2020·Cellular and Molecular Life Sciences : CMLS·Nawab John Dar, Gordon W Glazner
Jun 9, 2020·Psychopharmacology·Nikolaos KokrasChristina Dalla
Mar 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Michele Tufano, Graziano Pinna
Oct 1, 2020·International Journal of Molecular Sciences·Mikhail V VoroninSergei B Seredenin
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Oct 25, 2020·International Journal of Molecular Sciences·Luca Colucci-D'AmatoFloriana Volpicelli
Oct 18, 2020·Journal of Affective Disorders·Yeqing GuKaijun Niu
May 15, 2021·Frontiers in Psychiatry·Ajay SarawagiAnant Bahadur Patel
May 22, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Shiyi ChenYiping Ye

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