Direct and indirect interactions between antidepressant drugs and CYP2C6 in the rat liver during long-term treatment

European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology
Władysława Anna DanielJ Boksa

Abstract

The aim of the present study was to investigate the influence of tricyclic antidepressants (TADs: imipramine, amitriptyline, clomipramine, desipramine), selective serotonin reuptake inhibitors (SSRIs: fluoxetine, sertraline) and novel antidepressant drugs (mirtazapine, nefazodone) on the activity of CYP2C6 measured as a rate of warfarin 7-hydroxylation. The reaction was studied in control liver microsomes in the presence of the antidepressants, as well as in microsomes of rats treated intraperitoneally (i.p.) for one day or two weeks with pharmacological doses of the drugs (imipramine, amitriptyline, clomipramine, nefazodone at 10 mg/kg i.p.; desipramine, fluoxetine, sertraline at 5mg/kg i.p.; mirtazapine at 3mg/kg i.p.), in the absence of the antidepressants in vitro. Some of the investigated antidepressant drugs added to liver microsomes of control rats inhibited the rate of 7-hydroxylation of warfarin. The obtained K(i) values indicated that nefazodone and fluoxetine were the most potent inhibitors of the studied reaction (K(i)=13 and 23microM, respectively), while tricyclic antidepressants and sertraline were weak in this respect (K(i)=70-127microM). A one-day (i.e. 24h) exposure to fluoxetine and mirtazapine resulted in a ...Continue Reading

References

Oct 1, 1992·International Clinical Psychopharmacology·S J Warrington
Jan 1, 1991·Critical Reviews in Toxicology·L S Kaminsky, M J Fasco
Aug 1, 1990·Naunyn-Schmiedeberg's Archives of Pharmacology·W Daniel, K J Netter
Jan 1, 1990·Pharmacology & Therapeutics·D E Ryan, W Levin
May 1, 1986·The Journal of Pharmacy and Pharmacology·W Daniel, M Melzacka
Aug 1, 1973·European Journal of Clinical Pharmacology·K O'MalleyM J Turnbull
Nov 1, 1984·Naunyn-Schmiedeberg's Archives of Pharmacology·W DanielC Steffen
Mar 1, 1995·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·S J BaldwinR J Chenery
Jan 25, 1996·European Journal of Pharmacology·M PappP Willner
Jan 1, 1997·Pharmacology & Therapeutics·L S Kaminsky, Z Y Zhang
Nov 5, 1997·Archives of Biochemistry and Biophysics·H Yamazaki, T Shimada
Aug 13, 1999·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·W A DanielJ Wójcikowski
Apr 6, 2000·The Biochemical Journal·P Honkakoski, M Negishi
Sep 19, 2000·British Journal of Pharmacology·W A DanielJ Wójcikowski
Sep 14, 2002·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Jae-Gook ShinDavid A Flockhart
Oct 31, 2002·Human Psychopharmacology·Michael Maes
Dec 24, 2002·The Journal of Pharmacy and Pharmacology·Władysława A DanielJ Wójcikowski
Jun 20, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Kaoru KobayashiKan Chiba
Oct 14, 2003·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M Murray, K Murray
Jan 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·David J GranvilleRoberta A Gottlieb
Dec 15, 2004·Experimental and Molecular Pathology·Xi Jun HeKunio Doi
Oct 26, 2005·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·A HaduchW A Daniel

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Citations

Sep 20, 2011·European Journal of Drug Metabolism and Pharmacokinetics·Jillissa C MolnariAlan L Myers
Aug 9, 2013·Biochemical Pharmacology·Anna Sadakierska-ChudyWładysława A Daniel
Jan 11, 2013·Biological & Pharmaceutical Bulletin·Junichi IidaKiyomi Ito
Jul 10, 2013·Expert Opinion on Drug Metabolism & Toxicology·Roberto MandrioliMaria Augusta Raggi
Jul 4, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marta KotWładysława A Daniel
Jul 12, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Marta Kot, Władysława A Daniel
Oct 5, 2011·Biopharmaceutics & Drug Disposition·Rostislav VečeřaPavel Anzenbacher
Mar 1, 2012·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Alice ZachařováRostislav Večeřa
Mar 14, 2017·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Chaorui GuoNing Li
Jul 7, 2018·Biopharmaceutics & Drug Disposition·Shuhei FukunoHiroki Konishi
Sep 25, 2017·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marta KotWładysława A Daniel
Jun 11, 2015·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Marta RyszWładysława A Daniel
Jan 9, 2014·Pharmacological Reports : PR·Jacek WójcikowskiWładysława Anna Daniel
Apr 3, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Hui HeChao Yu
Jun 11, 2019·Molecular Medicine Reports·Yanyan WangYinglun Li
Aug 9, 2018·Naunyn-Schmiedeberg's Archives of Pharmacology·Adjia HamadjidaPhilippe Huot
Aug 5, 2020·Pharmacological Reports : PR·Anna HaduchWładysława A Daniel
Aug 28, 2021·International Journal of Molecular Sciences·Przemysław J DanekWładysława A Daniel

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