PMID: 43363Dec 1, 1979

Direct and reflex effects of nitroglycerin on the blood volume distribution, evaluated by regional weighing in the cat

The Journal of Pharmacy and Pharmacology
H I ChenC F Cheng

Abstract

The effects of nitroglycerin on the blood volume distribution were studied with a method of regional weighing in the anaesthetized cat. An i.v. bolus injection of nitroglycerin produced a dose-dependent decrease in arterial pressure accompanying a decrease in the thoracic blood volume. The latter change was associated with blood volume increases principally in the abdomen, and slightly in the hindquarters. Elimination of the cardiovascular reflex effects by carotid sinus denervation and cervical vagotomy signficantly enhanced and prolonged the following changes: the hypotension, the decrease in thoracic blood volume and the volume pooling in the abdomen. The magnitude of increase in hindquarters blood volume was not significantly affected by the denervation procedures, but the duration was much prolonged. The results indicate that the major site of nitroglycerin-induced venous pooling is in the splanchnic circulation. The peripheral venous pooling is produced at the expense of a decrease in the central or pulmonary blood volume. The secondary reflex adjustments tend to minimize the direct effects of nitroglycerin on the blood pressure and blood volume distribution.

References

Jan 1, 1961·Journal of Applied Physiology·C FELL, R F RUSHMER
Oct 1, 1964·The American Journal of Physiology·C FELL
Jan 1, 1937·The Journal of Clinical Investigation·S WeissF W Haynes
Jan 1, 1937·The Journal of Clinical Investigation·R W WilkinsS Weiss

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