Direct and Transcutaneous Vagus Nerve Stimulation for Treatment of Tinnitus: A Scoping Review.

Frontiers in Neuroscience
Natalia Yakunina, Eui-Cheol Nam

Abstract

Recent animal research has shown that vagus nerve stimulation (VNS) paired with sound stimuli can induce neural plasticity in the auditory cortex in a controlled manner. VNS paired with tones excluding the tinnitus frequency eliminated physiological and behavioral characteristics of tinnitus in noise-exposed rats. Several clinical trials followed and explored the effectiveness of VNS paired with sound stimuli for alleviating tinnitus in human subjects. Transcutaneous VNS (tVNS) has received increasing attention as a non-invasive alternative approach to tinnitus treatment. Several studies have also explored tVNS alone (not paired with sound stimuli) as a potential therapy for tinnitus. In this review, we discuss existing knowledge about direct and tVNS in terms of applicability, safety, and effectiveness in diminishing tinnitus symptoms in human subjects. This review includes all existing clinical and neuroimaging studies of tVNS alone or paired with acoustic stimulation in tinnitus patients and outlines the present limitations that must be overcome to maximize the potential of (t)VNS as a therapy for tinnitus.

References

Feb 1, 1995·Journal of Neurophysiology·E D YoungR A Conley
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·J S Bakin, N M Weinberger
Jul 1, 1997·The Journal of Neuropsychiatry and Clinical Neurosciences·M S MegaP Malloy
Mar 28, 1998·Science·M P Kilgard, M M Merzenich
Jul 22, 1998·Epilepsia·S C Schachter, C B Saper
Aug 26, 1998·Proceedings of the National Academy of Sciences of the United States of America·W MühlnickelH Flor
Aug 29, 1998·Behavioural Brain Research·G G BerntsonJ T Cacioppo
Feb 24, 2001·Autonomic Neuroscience : Basic & Clinical·H R Berthoud, W L Neuhuber
Nov 16, 2001·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·E Ben-Menachem
Feb 9, 2002·Clinical Anatomy : Official Journal of the American Association of Clinical Anatomists & the British Association of Clinical Anatomists·Elmar T Peuker, Timm J Filler
Sep 25, 2002·Neurology·Thomas R Henry
Dec 4, 2002·Epilepsia·Jaishree T NarayananChristopher G Filippi
Oct 18, 2003·Journal of Psychiatric Research·Jeong-Ho ChaeMark S George
Apr 20, 2004·The European Journal of Neuroscience·C PantevT Kubo
Oct 12, 2004·Trends in Neurosciences·Jos J Eggermont, Larry E Roberts
Apr 12, 2005·Neuroscience and Biobehavioral Reviews·Duncan A Groves, Verity J Brown
Aug 16, 2005·Progress in Neurobiology·Clive R Bramham, Elhoucine Messaoudi
Sep 29, 2005·The Journal of Clinical Psychiatry·Ziad NahasMark S George
Apr 28, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Charles B NemeroffStephen K Brannan
Nov 23, 2006·Acta Oto-laryngologica. Supplementum·Richard S TylerClaudia Coelho
Oct 25, 2007·Progress in Brain Research·Richard S TylerHelena Ji
Jan 1, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Andrew H MilbyGordon H Baltuch
Jun 17, 2008·Seizure : the Journal of the British Epilepsy Association·Kristl VonckPaul Boon
Jul 8, 2008·Biomedizinische Technik. Biomedical Engineering·Stefan DietrichRalf Ringler
Sep 3, 2009·Neurosurgical Focus·Dzenan LulicFernando L Vale
Jan 19, 2010·Proceedings of the National Academy of Sciences of the United States of America·Hidehiko OkamotoChristo Pantev
May 18, 2010·Journal of Clinical Psychopharmacology·Malek BajboujIsabella Heuser
Apr 1, 2007·Indian Journal of Psychiatry·V Rajmohan, E Mohandas
Jan 14, 2011·Nature·Navzer D EngineerMichael P Kilgard
Nov 15, 2011·Experimental Neurology·Jai A ShetakeMichael P Kilgard
Nov 15, 2011·Cerebral Cortex·Benjamin A PorterMichael P Kilgard
Aug 15, 2012·Frontiers in Psychiatry·Peter M KreuzerBerthold Langguth
Dec 15, 2012·Acta Oto-laryngologica·Jarmo LehtimäkiJukka Ylikoski

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