PMID: 15383567Sep 24, 2004Paper

Direct antigen presentation by a xenograft induces immunity independently of secondary lymphoid organs

The Journal of Immunology : Official Journal of the American Association of Immunologists
Bethany M TesarDaniel R Goldstein

Abstract

The location of immune activation is controversial during acute allograft rejection and unknown in xenotransplantation. To determine where immune activation to a xenograft occurs, we examined whether splenectomized alymphoplastic mice that possess no secondary lymphoid organs can reject porcine skin xenografts. Our results show that these mice rejected their xenografts, in a T cell-dependent fashion, at the same tempo as wild-type recipients, demonstrating that xenograft rejection is not critically dependent on secondary lymphoid organs. Furthermore, we provide evidence that immune activation in the bone marrow did not take place during xenograft rejection. Importantly, immunity to xenoantigens was only induced after xenotransplantation and not by immunization with porcine spleen cells, as xenografted mutant mice developed an effector response, whereas mutant mice immunized by porcine spleen cells via i.p. injection failed to do so. Moreover, we provide evidence that antixenograft immunity occurred via direct and indirect Ag presentation, as recipient T cells could be stimulated by either donor spleen cells or recipient APCs. Thus, our data provide evidence that direct and indirect Ag presentation by a xenograft induces immunit...Continue Reading

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Citations

Dec 16, 2004·Xenotransplantation·Reto M Baertschiger, Leo H Buhler
Oct 4, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wendy E WalkerDaniel R Goldstein
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew E GelmanDaniel Kreisel
Oct 20, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B M TesarD R Goldstein
Jul 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wenhao ChenLi Zhang
Sep 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marie-Caroline Dieu-NosjeanJacques Cadranel
Jan 29, 2011·Cancer Metastasis Reviews·Catherine Sautès-FridmanMarie-Caroline Dieu-Nosjean
Jun 17, 2010·International Journal of Hematology·Kanako ShimizuShin-ichiro Fujii
Sep 24, 2015·Nature Communications·Paolo CarregaGuido Ferlazzo
Sep 6, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·J WangK A Newell
Aug 14, 2010·The International Journal of Lower Extremity Wounds·Sonia GaucherFrédéric Batteux
May 6, 2021·Burns : Journal of the International Society for Burn Injuries·Suzan AlharbiPerenlei Enkhbaatar

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