PMID: 11333131May 3, 2001Paper

Direct antiproliferative effects of melatonin on two metastatic cell sublines of mouse melanoma (B16BL6 and PG19)

Melanoma Research
Samuel CosEmilio J Sánchez-Barceló

Abstract

The effects of melatonin on the growth of two highly tumorigenic rodent melanoma cells were studied in vitro. PG19, an amelanotic mouse melanoma cell line, and B16BL6, a melanotic melanoma cell line selected for its invasive potential in vitro, were cultured in the presence of different concentrations of melatonin (10 microM to 0.1 pM). Five days later, viable cells were determined in a haemocytometer by the trypan blue exclusion test. Melatonin at concentrations of 1 nM and 10 pM (within the range of concentrations that correspond to physiological night-time and daytime levels in human blood) significantly inhibited proliferation in both melanoma cell lines. Subphysiological (0.1 pM) or supraphysiological (10 microM to 100 nM) concentrations of melatonin lacked this effect. These results support the hypothesis that, at physiological concentrations, melatonin exerts a direct inhibitory effect on PG19 and B16BL6 cells proliferation.

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Citations

Feb 22, 2011·Journal of the National Cancer Institute·Eva S SchernhammerJiali Han
Sep 17, 2013·Expert Opinion on Therapeutic Targets·Mariano BizzarriRussel J Reiter
Dec 4, 2003·Clinical & Experimental Ophthalmology·Hayyam KiratliSevgül Bilgiç
Jun 26, 2009·Journal of Pineal Research·Ignacio BejaranoAna B Rodríguez
Feb 22, 2008·Molecular Reproduction and Development·Takaharu KawashimaBozenna Olszańska
May 17, 2008·Journal of Pineal Research·Leonardo Ortíz-LópezGloria Benítez-King
Aug 2, 2006·Journal of Pineal Research·Guillermo García-SantosCarmen Rodriguez
Feb 9, 2007·Journal of Pineal Research·Sara RubioJosé Quintana
Dec 14, 2012·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·María Antonia CidMaría Ángeles Trillo
Jul 6, 2019·Journal of Cellular Physiology·Mohammad Mirza-Aghazadeh-AttariBahman Yousefi
Aug 19, 2017·Molecular and Cellular Biochemistry·Roberto ParienteJavier Espino

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