Direct assessments of the antioxidant effects of propofol medium chain triglyceride/long chain triglyceride on the brain of stroke-prone spontaneously hypertensive rats using electron spin resonance spectroscopy

Anesthesiology
Kyo KobayashiMasaichi-Chang-Il Lee

Abstract

Antioxidant anesthetics such as propofol (2,6-diisopropylphenol) directly inhibit lipid peroxidation via the generation of reactive oxygen species. Currently, there are no other studies regarding the direct effects of propofol medium chain triglyceride/long chain triglyceride (MCT/LCT) on reactive oxygen species generation or in experimental models of reactive oxygen species-induced oxidative stress in the brain. The authors investigated the effects of propofol MCT/LCT on reactive oxygen species (hydroxyl radical or superoxide) by electron spin resonance spin trapping with 5,5-dimethyl-1-pyrroline-N-oxide. The effects of propofol MCT/LCT on oxidative stress in the brain of Wistar-Kyoto rats or stroke-prone spontaneously hypertensive rats were investigated by using an in vivo L-band electron spin resonance system to monitor the decay rate of 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl as a nitroxyl spin probe. These studies provided direct evidence that propofol MCT/LCT inhibited hydroxyl radical generation, but not superoxide generation. Regarding the hydroxyl radical from the Fenton system, it is likely to be due to the scavenging effects of vehicle. Anesthesia with propofol MCT/LCT reduced the degree of the high ...Continue Reading

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Citations

Jun 21, 2011·Journal of Anesthesia·Mitsuuru HataMasaichi-Chang-Il Lee
Dec 21, 2011·Journal of Neurotrauma·Michèle TanguyYannick Malledant
Nov 5, 2010·Biological & Pharmaceutical Bulletin·Satomi Koya-MiyataShigeharu Fukuda
May 3, 2008·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masaichi-Chang-il Lee
Dec 1, 2011·Journal of Clinical Biochemistry and Nutrition·Fumihiko YoshinoMasaichi-Chang-Il Lee
Sep 11, 2012·Journal of Clinical Biochemistry and Nutrition·Shuta SugiyamaMasaichi-Chang-Il Lee
Jan 24, 2013·Journal of Clinical Biochemistry and Nutrition·Masaichi-Chang-Il Lee
Jan 20, 2015·Anesthesiology and Pain Medicine·Ghazaleh Taheri MoghadamAkram Ranjbar
Jun 26, 2014·Neurochemical Research·Likui WangYuxian Shen
Dec 31, 2011·Neuroscience Letters·Fumihiko YoshinoMasaichi Chang-il Lee
Nov 30, 2013·Pharmaceutical Development and Technology·Kyo KobayashiMasaichi-Chang-Il Lee
Apr 22, 2015·The Journal of Surgical Research·Mian GeZiqing Hei
Jan 21, 2012·Archives of Oral Biology·Fumihiko YoshinoMasaichi-Chang-il Lee
Apr 27, 2012·Anesthesiology·Weiguang LiChenggang Zhang
Dec 6, 2017·Magnetic Resonance in Chemistry : MRC·D David JebarajA Milton Franklin Benial
Feb 13, 2020·Journal of Applied Oral Science : Revista FOB·Masahiro ToShun-Suke Takahashi
Sep 27, 2016·The Journal of Veterinary Medical Science·Reeko SatoMasahiro Yamasaki
Feb 9, 2017·Genome Biology and Evolution·Hongan LongMichael Lynch
Sep 8, 2017·Journal of Dental Anesthesia and Pain Medicine·Ji-Young YoonEok-Nyun Kim
Jan 8, 2020·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Li-Yuan WangJun Ma
Nov 30, 2019·Journal of Clinical Biochemistry and Nutrition·Tomoko KomatsuMasaichi Chang-Il Lee
Jul 14, 2017·Scientific Reports·Ayaka YoshidaFumihiko Yoshino
Oct 13, 2020·Journal of Clinical Biochemistry and Nutrition·Tomoko KomatsuMasaichi Chang-Il Lee
Jul 7, 2021·International Journal of Clinical Practice·Hilal KutluhanBanu Cevik

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