Direct association of the HPV16 E7 oncoprotein with cyclin A/CDK2 and cyclin E/CDK2 complexes.

Virology
Christine L Nguyen, K Münger

Abstract

The human papillomavirus (HPV) E7 oncoprotein has been shown to associate with cyclin/CDK2 complexes. Here we present evidence that HPV E7 proteins can associate with cyclin A/CDK2 and cyclin E/CDK2 complexes in cells that lack retinoblastoma tumor suppressor family members through sequences outside of the core retinoblastoma tumor suppressor binding site. Moreover, we show that HPV16 E7 can directly associate with cyclin A/CDK2 and cyclin E/CDK2 complexes. These results suggest that cyclin/CDK2 complexes may be components of HPV E7-associated cellular complexes that do not contain retinoblastoma tumor suppressor family members.

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Citations

Apr 10, 2014·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Andrea ArenzClaus Wittekindt
Sep 22, 2011·Der Pathologe·G Assmann, K Sotlar
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May 8, 2020·Infectious Agents and Cancer·Shaian TavakolianEbrahim Faghihloo
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May 10, 2021·Journal of Gynecology Obstetrics and Human Reproduction·Mohammad AbbasFarzana Mahdi
Sep 14, 2021·Molecular Oncology·Luigi Marongiu, Heike Allgayer

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