Direct binding of human NK cell natural cytotoxicity receptor NKp44 to the surfaces of mycobacteria and other bacteria.

Infection and Immunity
Semih EsinMario Campa

Abstract

Our previous studies demonstrated that Mycobacterium bovis bacillus Calmette-Guérin (BCG) can directly interact with human NK cells and induce the proliferation, gamma interferon production, and cytotoxic activity of such cells without the need for accessory cells. Thus, the aim of the present study was to identify the putative receptor(s) responsible for the recognition of BCG by human NK cells and potentially involved in the activation of NK cells. To this end, we first investigated the surface expression of three NK cell-activating receptors belonging to the natural cytoxicity receptor (NCR) family on highly purified human NK cells upon in vitro direct stimulation with BCG. An induction of the surface expression of NKp44, but not of NKp30 or NKp46, was observed after 3 and 4 days of in vitro stimulation with live BCG. The NKp44 induction involved mainly a particular NK cell subset expressing the CD56 marker at high density, CD56(bright). In order to establish whether NKp44 could directly bind to BCG, whole BCG cells were stained with soluble forms of the three NCRs chimeric for the human immunoglobulin G (IgG) Fc fragment (NKp30-Fc, NKp44-Fc, NKp46-Fc), followed by incubation with a phycoerythrin (PE)-conjugated goat anti-hu...Continue Reading

References

Nov 26, 1998·Progress in Lipid Research·C E BarryY Yuan
Sep 6, 2001·European Journal of Immunology·T I ArnonO Mandelboim
Nov 8, 2001·Trends in Immunology·M A CooperM A Caligiuri
Dec 26, 2001·Nature Immunology·Alessandro MorettaLorenzo Moretta
Mar 22, 2002·Nature Reviews. Immunology·R Medzhitov
Aug 30, 2003·Molecular and Biochemical Parasitology·Ingeborg BeckerArmando Isibasi
Sep 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Akiko Kikuchi-MakiKerry S Campbell
Dec 20, 2003·The EMBO Journal·Lorenzo Moretta, Alessandro Moretta
Mar 31, 2005·Trends in Immunology·Cristina BottinoAlessandro Moretta
Apr 12, 2005·Nature Immunology·Tal I ArnonOfer Mandelboim
Sep 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ramakrishna VankayalapatiPeter F Barnes
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pablo SchierlohMaría C Sasiain
Jan 21, 2006·Immunology·Geraldine M O'ConnorClair M Gardiner
Jun 13, 2006·Current Opinion in Immunology·Melissa B Lodoen, Lewis L Lanier
Mar 24, 2007·Nature Reviews. Immunology·Kirsty C Newman, Eleanor M Riley

❮ Previous
Next ❯

Citations

Jan 23, 2013·Immunology and Cell Biology·Naomi H Philip, David Artis
Oct 19, 2011·Infection and Immunity·Christine M GonzalesJanice J Endsley
Jun 12, 2009·Journal of Virology·Mostafa JarahianFrank Momburg
Jun 2, 2011·Journal of Biomedicine & Biotechnology·M Gordon Joyce, Peter D Sun
Dec 25, 2013·Immunology and Cell Biology·Philip H KruseEric Vivier
Mar 4, 2014·Seminars in Immunology·Mariella Della ChiesaAlessandro Moretta
Dec 10, 2014·Best Practice & Research. Clinical Rheumatology·Mark AsquithJames T Rosenbaum
Aug 24, 2011·Journal of Biomedicine & Biotechnology·Francesco MarrasAndrea De Maria
May 2, 2012·Cellular and Molecular Life Sciences : CMLS·Einat SeidelOfer Mandelboim
Feb 19, 2013·Trends in Immunology·Joachim KochOfer Mandelboim
Sep 3, 2008·Microbes and Infection·Daniel S KorbelUlrich E Schaible
Nov 17, 2009·Immunological Reviews·Jessica A HamermanClifford A Lowell
Oct 7, 2015·Frontiers in Immunology·Lea-Maxie Haag, Britta Siegmund
Aug 8, 2015·Periodontology 2000·Asaf WilenskyLior Shapira
Dec 16, 2011·Comparative Immunology, Microbiology and Infectious Diseases·Nazneen SiddiquiJayne Hope
May 25, 2013·Annals of Medicine·Runyi A LamStephan Gasser
Apr 25, 2012·Journal of Immunotoxicology·Michael BrusilovskyAngel Porgador
Jun 13, 2014·Gut Microbes·Markus B GeukingKathy D McCoy
Feb 5, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tao ChenQin Ning
May 26, 2012·Microbes and Infection·Stephanie Jost, Marcus Altfeld
Apr 20, 2014·Frontiers in Immunology·Monica KilligChiara Romagnani
Mar 29, 2014·Frontiers in Immunology·Simona SivoriEmanuela Marcenaro
Sep 18, 2016·Comparative Immunology, Microbiology and Infectious Diseases·Anja SipkaYnte Schukken
Oct 25, 2016·Frontiers in Immunology·Aranzazu Cruz-Adalia, Esteban Veiga
Oct 30, 2016·Expert Review of Hematology·Stanislaw SchmidtThomas Lehrnbecher
Sep 1, 2017·Immunological Reviews·Liudmila Britanova, Andreas Diefenbach
Aug 21, 2014·Journal of Leukocyte Biology·Chia-Chen LuHsin-Chih Lai
Jan 6, 2009·Immunological Reviews·Lewis L Lanier
Mar 2, 2019·Journal of Leukocyte Biology·Christopher H ModyShu Shun Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.