PMID: 7515181May 24, 1994Paper

Direct binding of myelin basic protein and synthetic copolymer 1 to class II major histocompatibility complex molecules on living antigen-presenting cells--specificity and promiscuity

Proceedings of the National Academy of Sciences of the United States of America
M Fridkis-HareliM Sela

Abstract

Copolymer 1 (Cop 1) is a synthetic basic random copolymer of amino acids that has been shown to be effective in suppression of experimental allergic encephalomyelitis and is being tested as a candidate drug for multiple sclerosis. It has been previously demonstrated that Cop 1 is immunologically cross-reactive with the autoantigen myelin basic protein (BP) and competitively inhibits the response to BP of T-cell lines and clones of different major histocompatibility complex (MHC) restrictions, of both mouse and human origin. In the present study we demonstrated the direct binding of Cop 1, using its biotinylated derivative, to MHC molecules on living antigen-presenting cells. Binding of biotinylated BP and peptide p84-102 (an immunodominant epitope of BP) was also demonstrated. Cop 1 and BP bound in a promiscuous manner to different types of antigen-presenting cells of various H-2 and HLA haplotypes. The specificity of the binding was confirmed by its inhibition with either the relevant anti-MHC class II antibodies or unlabeled analogs. Cop 1 exhibited the most extensive and fast binding to antigen-presenting cells. In addition, Cop 1 inhibited the binding of biotinylated derivatives of BP and of p84-102 to the MHC class II mole...Continue Reading

References

Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·D TeitelbaumM Sela
Oct 1, 1992·The Journal of Experimental Medicine·J HammerF Sinigaglia
Jan 1, 1990·International Immunology·R BuschJ B Rothbard
Aug 1, 1991·Immunology Today·K W WucherpfennigD A Hafler
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·D TeitelbaumR Arnon
Jan 1, 1991·Annual Review of Immunology·J B Rothbard, M L Gefter
Jan 1, 1990·Annual Review of Immunology·S S Zamvil, L Steinman
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D TeitelbaumM Sela
Jun 1, 1989·Journal of Neuroimmunology·J R RichertM W Kies
Aug 1, 1971·European Journal of Immunology·D TeitelbaumM Sela
Oct 8, 1965·Science·R B Merrifield
Jul 1, 1993·The Journal of Experimental Medicine·R M ChiczJ L Strominger
Feb 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·E ZismanE Mozes

❮ Previous
Next ❯

Citations

Apr 15, 2000·Journal of Clinical Apheresis·R Weinstein
Jul 16, 2008·Inflammatory Bowel Diseases·Albrecht NeesseMartin Steinkamp
Jul 31, 1998·Protein Science : a Publication of the Protein Society·M Sela
Aug 12, 2009·Journal of Neural Transmission·Ruth Arnon, Rina Aharoni
Feb 21, 2004·Journal of Neuroimmunology·Stefan JungKlaus Toyka
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Martin S WeberScott S Zamvil
May 3, 2003·Pharmacology & Therapeutics·Suhayl Dhib-Jalbut
Mar 4, 2000·Journal of Neuroimmunology·M ZhangI Gery
Nov 10, 2000·Advanced Drug Delivery Reviews·M L Hedley
Jan 26, 2000·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·M Sela
Apr 23, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·M SchmiedD A Hafler
Aug 7, 2007·Nature Medicine·Martin S WeberScott S Zamvil
Sep 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ruth Arnon, Rina Aharoni
Sep 30, 2010·Proceedings of the National Academy of Sciences of the United States of America·Rakel CarpinteroDanielle Burger
Feb 13, 2010·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Binbin YangHuiping Yuan
Apr 13, 2006·Rejuvenation Research·Michael Sela
Sep 7, 2001·Transplantation·R AharoniM Sela
Jan 22, 2005·Annual Review of Medicine·Jingwu Zhang, George Hutton
Mar 6, 2002·The Journal of Clinical Investigation·Nitin J KarandikarMichael K Racke
Oct 19, 2013·Journal of Neuroinflammation·Madhan ThamilarasanUwe Klaus Zettl
Dec 27, 2007·PloS One·Zuojia LiuErkang Wang
Apr 1, 2007·Neuropsychiatric Disease and Treatment·Alex TselisRobert P Lisak

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.