Direct C-OH/P(O)-H dehydration coupling forming phosphine oxides

Organic & Biomolecular Chemistry
Long ChenLi-Biao Han

Abstract

A t-BuONa-mediated C-OH/P(O)-H cross dehydration coupling to produce alkylphosphine oxides is developed. This reaction employed readily available alcohols and P(O)-H compounds as the starting materials, providing an efficient alternative method for constructing sp3 C-P bonds. A reasonable reaction path involving dehydration and subsequent regio-selective hydrophosphorylation of the resulting alkenes was proposed.

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Citations

Sep 19, 2018·Chemical Communications : Chem Comm·Xiangyang WoTeck-Peng Loh
Nov 11, 2020·Organic & Biomolecular Chemistry·Dan-Yang WangYan-Chao Wu
Feb 23, 2021·Organic & Biomolecular Chemistry·Wei-Ze Li, Zhong-Xia Wang

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Methods Mentioned

BETA
NMR

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