Direct cardiac electrophysiologic effects of sufentanil and vecuronium in isolated guinea-pig hearts

Acta Anaesthesiologica Scandinavica
G WeberU Stark

Abstract

Sufentanil and vecuronium are commonly used simultaneously in anaesthesia. Bradycardia and asystole have been described immediately after the administration of these two compounds. Therefore, the purpose of the present study was to evaluate the direct cardiac effects of sufentanil and vecuronium in all parts of the cardiac pacemaker and conduction system. The electrophysiological effects of sufentanil and vecuronium were studied in isolated spontaneously beating guinea-pig hearts perfused by the method of Langendorff. At a concentration of 0.1 mumol/l sufentanil a significant reduction of the spontaneous sinus rate, prolongation of atrioventricular, intraventricular and His' bundle conduction could be observed. The highest concentration of 10 mumol/l of sufentanil led to an overall slowing of conduction velocity and to an profound showing of spontaneous sinus rate. AV nodal as well as atrial and ventricular refractoriness were markedly prolonged at this high concentration of sufentanil. In contrast, during perfusion with vecuronium at a concentration of 0.1 mumol/l up to 10 mumol/l no significant effects on cardiac conduction and pacemaker activity could be observed. In conclusion, the electrophysiological effects of sufentanil...Continue Reading

References

Jun 1, 1992·Journal of Cardiothoracic and Vascular Anesthesia·L AlvarezJ L Castillo-Olivares
Jan 1, 1988·Anesthesiology·P Yeaton, L Teba
Dec 18, 1969·The New England Journal of Medicine·E LowensteinM B Laver
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Jul 1, 1984·Journal of the Autonomic Nervous System·J M LoebJ M deTarnowsky

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Citations

Dec 7, 2005·The American Journal of Surgical Pathology·Erika ResetkovaNour Sneige
Dec 7, 2013·British Journal of Anaesthesia·C StaikouE Stavroulakis
Nov 13, 2007·Acta Anaesthesiologica Scandinavica·M YanG Chen
Jun 30, 2018·Annual Review of Phytopathology·Danny L CoyneHerbert Talwana
Jan 23, 2018·International Journal of Toxicology·Shiv Kumar YadavRahul Bhattacharya

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