Direct Causal Networks for the Study of Transcranial Magnetic Stimulation Effects on Focal Epileptiform Discharges

International Journal of Neural Systems
Dimitris Kugiumtzis, Vasilios K Kimiskidis

Abstract

Transcranial magnetic stimulation (TMS) can have inhibitory effects on epileptiform discharges (EDs) of patients with focal seizures. However, the brain connectivity before, during and after EDs, with or without the administration of TMS, has not been extensively explored. To investigate the brain network of effective connectivity during ED with and without TMS in patients with focal seizures. For the effective connectivity a direct causality measure is applied termed partial mutual information from mixed embedding (PMIME). TMS-EEG data from two patients with focal seizures were analyzed. Each EEG record contained a number of EDs in the majority of which TMS was administered over the epileptic focus. As a control condition, sham stimulation over the epileptogenic zone or real TMS at a distance from the epileptic focus was also performed. The change in brain connectivity structure was investigated from the causal networks formed at each sliding window. The PMIME could detect distinct changes in the network structure before, within, and after ED. The administration of real TMS over the epileptic focus, in contrast to sham stimulation, terminated the ED prematurely in a node-specific manner and regained the network structure as if...Continue Reading

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Citations

Apr 8, 2016·International Journal of Neural Systems·Loukianos SpyrouSaeid Sanei
Feb 22, 2017·Frontiers in Neuroinformatics·Juan García-PrietoErnesto Pereda
Oct 11, 2017·Frontiers in Neurology·Udaya SeneviratneWendyl Jude D'Souza
May 1, 2019·Brain Topography·Dezhong YaoPedro A Valdés Sosa
Oct 28, 2019·Medical & Biological Engineering & Computing·Pantelis VafidisDimitris Kugiumtzis
Nov 23, 2017·Frontiers in Neuroscience·Li DongDezhong Yao
Apr 12, 2019·Brain Topography·Shiang HuPedro A Valdes-Sosa
Jan 8, 2021·Frontiers in Neuroscience·Ofri Levy-LamdanHilla Fogel
Jul 9, 2017·Journal of Neuroscience Methods·Elsa SiggiridouDimitris Kugiumtzis

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