Direct comparison of 129 Xe diffusion measurements with quantitative histology in human lungs.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
Robert P ThomenJason C Woods

Abstract

Chronic obstructive pulmonary disease (COPD) is an irreversible lung disease characterized by small-airway obstruction and alveolar-airspace destruction. Hyperpolarized 129 Xe diffusion MRI of lung is a promising biomarker for assessing airspace enlargement, but has yet to be validated by direct comparison to lung histology. Here we have compared diffusion measurements of hyperpolarized (HP) 129 Xe in explanted lungs to regionally matched morphological measures of airspace size. Explanted lungs from five COPD patients and two idiopathic pulmonary fibrosis (IPF) patients were imaged using MRI with hyperpolarized 129 Xe using a two-b-value gradient-echo diffusion sequence, and 34 histological samples were taken from these lungs for quantitative histology. Mean-linear-intercept (Lm ) was compared with spatially matched measures of apparent diffusion coefficient (ADC) from 129 Xe MRI. The mean ADC from COPD lung samples was 0.071 ± 0.011 cm2 /s, and for IPF lungs was 0.033 ± 0.001 cm2 /s (P < 10-15 between groups). The mean Lm in COPD samples was 0.076 ± 0.027 cm and 0.041 ± 0.004 cm in IPF (P = 2.7 × 10-7 between groups). The Pearson-correlation between ADC and Lm measurements was r = 0.59. Diffusion MRI of HP 129 Xe quantifies re...Continue Reading

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Citations

Feb 16, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexei OuriadovUNKNOWN Canadian Respiratory Research Network
Mar 7, 2017·Academic Radiology·Eric A Hoffman, John D Newell
Apr 24, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Kai RuppertRahim R Rizi
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Oct 20, 2018·The European Respiratory Journal·George R Washko, Grace Parraga
Nov 9, 2019·The European Respiratory Journal·Rachel L Eddy, Grace Parraga
Nov 26, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alexei OuriadovGrace Parraga
Dec 24, 2019·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ming ZhangXin Zhou
Sep 15, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Adam MaunderJim M Wild
Jan 15, 2019·Journal of Magnetic Resonance Imaging : JMRI·Andrew WestcottAlexei Ouriadov
Apr 1, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Agilo L KernJens Vogel-Claussen
Oct 6, 2020·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter J NiedbalskiZackary I Cleveland
Feb 7, 2021·Journal of Perinatology : Official Journal of the California Perinatal Association·Nara S HiganoJason C Woods
Feb 25, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ho-Fung ChanJim M Wild
Mar 6, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Matthew M WillmeringJason C Woods
Feb 27, 2021·Progress in Nuclear Magnetic Resonance Spectroscopy·Helen MarshallJim M Wild
Jun 10, 2021·The British Journal of Radiology·Neil J StewartJim M Wild
Jul 14, 2021·European Radiology·Caohui DuanXin Zhou
Sep 4, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter J NiedbalskiJason C Woods
Nov 4, 2021·NMR in Biomedicine·Abdullah S BdaiwiZackary I Cleveland

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