Direct comparison of five serum biomarkers in early diagnosis of hepatocellular carcinoma

Cancer Management and Research
Hongda ChenMin Dai

Abstract

Although a number of serum biomarkers for detection of hepatocellular carcinoma (HCC) have been explored, their exact diagnostic value remains unclear. We aimed to conduct a direct comparison of five representative serum biomarkers for detecting HCC and to derive multi-marker prediction algorithms. In total, 846 patients were recruited from three hospitals in China, including 202 HCC patients, 226 liver cirrhosis patients, 215 chronic hepatitis B virus-infected patients, and 203 healthy volunteers. Serum levels of alpha-fetoprotein (AFP), lens culinaris agglutinin-reactive AFP (AFP-L3), des-gamma-carboxyprothrombin (DCP), squamous cell carcinoma antigen, and centromere protein F autoantibody were measured by ELISA. The diagnostic performances of individual biomarkers and multi-marker combinations were evaluated by receiver operating characteristics analysis. The bootstrapping method was adopted to adjust for potential overfitting of all diagnostic indicators. DCP exhibited the best diagnostic performance, with areas under the curve (AUC) for detecting HCC of 0.82 (95% CI 0.64-0.80) and sensitivity of 65.2% (95% CI 63.3-82.1%) at 90% specificity. Of note, DCP showed similar diagnostic efficacy for detecting AFP-positive and AFP-...Continue Reading

Citations

Jun 17, 2020·Clinical and Molecular Hepatology·Takako Inoue, Yasuhito Tanaka
Sep 15, 2020·Frontiers in Oncology·Ting Wang, Kun-He Zhang
Aug 1, 2019·World Journal of Clinical Cases·Lavinia Alice Balaceanu
Mar 13, 2019·Proceedings of the National Academy of Sciences of the United States of America·Chunfeng QuYuchen Jiao
Aug 28, 2020·Journal of Cancer Research and Clinical Oncology·Amr Shaaban HanafyAhmed A Alnagar
Apr 16, 2021·The Cochrane Database of Systematic Reviews·Agostino ColliGiovanni Casazza
Jul 3, 2021·International Journal of Molecular Sciences·Mengtao XingJian-Ying Zhang

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Methods Mentioned

BETA
imaging techniques
ELISA

Software Mentioned

R package “ Daim
R

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