Direct comparison of histology of microbleeds with postmortem MR images: a case report

Cerebrovascular Diseases
Shinsui TatsumiToru Yamamoto


Although the clinical significance of so-called microbleeds (MBs) in gradient-echo MR images (GRE-MRI) has been extensively researched, the histopathological evaluation is notably insufficient. Postmortem GRE-MRI was obtained of water-immersed formalin-fixed tissue blocks from a 97-year-old hypertensive woman with 9 antemortem MBs. Histologic slides were compared with those of MRI. Microscopic examination revealed clusters of hemosiderin-laden macrophages in 8 MBs and arteriolar pseudocalcification in 1 MB in the left pallidum. Hypertensive microangiopathies were found in 5 lesions. The sizes of the lesions with hemosiderin deposits were roughly comparable with the MBs of GRE-MRI. All of the MBs but for 1 exception were proved to be hemosiderin deposits and frequently associated with hypertensive microangiopathy.


Jul 11, 2013·European Radiology·Sven HallerKarl-Olof Lovblad
Nov 10, 2012·Neurology International·Ryuji SakakibaraTatsuya Yamamoto
Jul 6, 2014·Alzheimer's Research & Therapy·Sergi Martinez-RamirezAnand Viswanathan
Sep 2, 2014·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Junpei NagasawaKen Ikeda
Sep 10, 2013·Revue neurologique·K MuraoC Cordonnier
Dec 8, 2015·Biomarkers in Medicine·Sara Shams, Lars-Olof Wahlund
Aug 14, 2015·Acta Neuropathologica Communications·Enikö KövariGabriel Gold
Sep 8, 2016·BMC Medicine·Kirsty E McAleeseJohannes Attems
Mar 24, 2017·Brain : a Journal of Neurology·Andreas CharidimouSteven M Greenberg
Jun 17, 2015·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Sergi Martinez-RamirezAnand Viswanathan
Mar 21, 2018·Radiology·Sven HallerFrederik Barkhof
Nov 23, 2011·Cerebrovascular Diseases·A ShoamaneshO Benavente
Mar 21, 2018·Cerebrovascular Diseases·Celine GuidouxPierre Amarenco
Sep 11, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Catherine A HumphreysColin Smith
May 14, 2011·Stroke; a Journal of Cerebral Circulation·Jeroen D C GoosMike P Wattjes
Aug 8, 2009·Stroke; a Journal of Cerebral Circulation·Julie StaalsJan Lodder
Sep 19, 2009·Stroke; a Journal of Cerebral Circulation·Jeroen D C GoosWiesje M van der Flier
Oct 15, 2013·International Journal of Urology : Official Journal of the Japanese Urological Association·Ryuji SakakibaraMasashi Yano
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Miharu SamurakiMasahito Yamada
Dec 11, 2013·Alzheimer Disease and Associated Disorders·Saima HilalNarayanaswamy Venketasubramanian
Jul 24, 2019·Frontiers in Neuroanatomy·Amaury De BarrosPatrice Péran
Aug 10, 2019·Neuroradiology·Sven HallerEnikö Kövari
Dec 23, 2009·Journal of Magnetic Resonance Imaging : JMRI·Muhammad AyazWolff M Kirsch
Oct 15, 2019·Brain : a Journal of Neurology·Allison D GriffinLawrence L Latour

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Entire Right Internal Carotid Artery
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