Direct comparison of neck pinhole dual-tracer and dual-phase MIBI accuracies with and without SPECT/CT for parathyroid adenoma detection and localization

Clinical Nuclear Medicine
Sherif I HeibaLale Kostakoglu

Abstract

There is uncertainty about accuracies of dual-phase (DP) and dual-tracer (DT) parathyroid scintigraphy with the newly added SPECT/CT. Although SPECT/CT was shown to be helpful in parathyroid adenoma (PA) localization, it may not have optimal resolution as pinhole. This study directly compared diagnostic accuracies and confidences of various imaging protocols on same patients. One hundred fifty-five patients with pathologically confirmed diagnosis were included. Pinhole DP, pinhole DT, pinhole DP SPECT/CT, pinhole DT SPECT/CT, and SPECT/CT with only pinhole-delayed MIBI (D) were reviewed for accuracies and certainties of PA diagnosis/localization. Parathyroid adenomas were classified as clearly or unclearly distinguishable from thyroid. Furthermore, the contribution of pinhole DP to pinhole DT SPECT/CT was assessed. Of 153 PAs, the correct diagnosis/localization was significantly higher by pinhole DT SPECT/CT than pinhole DP SPECT/CT, SPECT/CT D, pinhole DT alone, and DP alone. Parathyroid adenomas were clearly more distinguished from thyroid in pinhole DT than DP with/without SPECT/CT. Consequently, PA diagnosis certainty was higher in pinhole DT than DP, whereas PA localization certainty was higher in both with SPECT/CT. In pi...Continue Reading

References

Jun 22, 2005·Archives of Otolaryngology--head & Neck Surgery·Nicholas Y MehtaBrendan C Stack
Sep 10, 2005·Seminars in Nuclear Medicine·Christopher J PalestroGene G Tronco
Jan 24, 2007·Clinical Nuclear Medicine·Suk Chul KimChun K Kim
Jun 19, 2007·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·William C LavelyHarvey A Ziessman
Oct 7, 2008·Nuclear Medicine Communications·Ivan A Ho ShonLeigh W Delbridge
Nov 11, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Donald R NeumannFrank P Difilippo
Nov 15, 2008·Journal of Nuclear Medicine Technology·Maria B TomasKenneth J Nichols
May 28, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Elif HindiéUNKNOWN Parathyroid Task Group of the EANM
Jun 1, 2010·Otolaryngologic Clinics of North America·David Chien, Heather Jacene
Oct 18, 2011·Nuclear Medicine Communications·Kenneth J NicholsChristopher J Palestro
Feb 23, 2013·International Journal of Molecular Imaging·Virpi TunninenMarko Seppänen
Mar 6, 2013·Nuclear Medicine Communications·Lishi ZhenJigang Yang

❮ Previous
Next ❯

Citations

Dec 30, 2016·Clinical Nuclear Medicine·Paul LalireDavid Morland
Nov 29, 2017·International Journal of Molecular Imaging·Virpi TunninenMarko Seppänen
Aug 19, 2015·Clinical Nuclear Medicine·Christina BluemelKen Herrmann

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Sandra Rodríguez-CarranzaJuan A Rull
Annals of Nuclear Medicine
Vani Vijayakumar, Matthew E Anderson
Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
William C LavelyHarvey A Ziessman
© 2021 Meta ULC. All rights reserved