Direct compression properties of chitin and chitosan

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V
Viviana García MirJouko Yliruusi

Abstract

Deformation and compaction properties of native amino poly-saccharides chitin and chitosan were studied and compared with those obtained with established pharmaceutical direct compression excipients. An instrumented single-punch tablet machine was used for tablet compaction. The following compression parameters were evaluated: a ratio of crushing strength and compression pressure, plasticity and elasticity factor (PF and EF), tensile strength and R-value. Chitin and chitosan were found to have a marked tendency to plastic deformation, and both showed a good compression behaviour compared with the other direct compression excipients including microcrystalline cellulose. It is concluded that chitin and chitosan are potential co-excipients for direct compression applications.

Citations

Dec 17, 2009·AAPS PharmSciTech·Linda SalbuIngunn Tho
Mar 20, 2010·AAPS PharmSciTech·Viviana García MirJouko Yliruusi
Jul 23, 2013·AAPS PharmSciTech·Anna PenkinaJyrki Heinämäki
Apr 4, 2014·Chemical & Pharmaceutical Bulletin·Shin-ichiro KimuraNoriyuki Namiki
Apr 20, 2013·Drug Development and Industrial Pharmacy·Joe M ViljoenAwie F Kotzé
Mar 10, 2015·Chemical & Pharmaceutical Bulletin·Yasunori IwaoShigeru Itai
Feb 11, 2015·International Journal of Pharmaceutics·Ahmad Bani-JaberShigeru Itai
May 7, 2016·Water Science and Technology : a Journal of the International Association on Water Pollution Research·Hamou MoussoutCharaf El Akili
Jun 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna Kaczmarek-Kędziera
Nov 17, 2016·Journal of Pharmaceutics·Yuritze Alejandra Aguilar-López, Leopoldo Villafuerte-Robles

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