Direct contact transmission of three different foot-and-mouth disease virus strains in swine demonstrates important strain-specific differences

The Veterinary Journal
J M PachecoLuis L Rodriguez

Abstract

A novel direct contact transmission model for the study of foot-and-mouth disease virus (FMDV) infection of swine was utilized to investigate transmission characteristics of three FMDV strains belonging to serotypes A, O and Asia1. Each strain demonstrated distinct transmission characteristics and required different exposure times to achieve successful contact transmission. While a 4h exposure was sufficient for strain A24 Cruzeiro (A24Cru), both O1 Manisa and Asia1 Shamir transmission required 18 h or more. Viral excretion levels from donors (for all three strains) and virus present in room air (for A24Cru and O1 Manisa) were evaluated and associated with clinical signs and observed transmission pattern. Although all directly inoculated donor animals showed acute FMD, A24Cru had the highest levels of viral shedding in saliva and nasal swabs followed by O1 Manisa and Asia1 Shamir. Virus levels in room air were higher and were detected longer for A24Cru than for O1 Manisa. These results provide direct evidence for important strain-specific variation in transmission characteristics and emphasize the need for thorough evaluation of different FMDV viral strains using a well defined contact transmission methodology. This information...Continue Reading

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Citations

May 3, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Eva Perez-MartinTeresa de los Santos
Aug 26, 2015·Transboundary and Emerging Diseases·J M PachecoL L Rodriguez
Jun 1, 2016·Frontiers in Veterinary Science·Carolina StenfeldtJonathan Arzt
Jun 18, 2016·Frontiers in Veterinary Science·Amy C KinsleyAndres M Perez
Dec 6, 2016·Frontiers in Veterinary Science·Carolina StenfeldtJonathan Arzt
Feb 26, 2019·Scientific Reports·Jonathan ArztCarolina Stenfeldt
Jul 1, 2020·Frontiers in Veterinary Science·Carolina StenfeldtJonathan Arzt
Aug 28, 2020·Frontiers in Veterinary Science·Gisselle N MedinaFayna Diaz-San Segundo
Jun 11, 2021·Royal Society Open Science·Wendy C TurnerKyrre Kausrud

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