Direct contact with particulate matter increases oxidative stress in different brain structures

Inhalation Toxicology
Lucas Sagrillo FagundesCláudia Ramos Rhoden

Abstract

Several experimental and epidemiological studies have demonstrated the neurological adverse effects caused by exposure to air pollution, specifically in relation to pollutant particulate matter (PM). The objective of this study was to investigate the direct effect of PM in increased concentrations in different brain regions, as well as the mechanisms involving its neurotoxicity, by evaluating oxidative stress parameters in vitro. Olfactory bulb, cerebral cortex, striatum, hippocampus and cerebellum of rats were homogenized and incubated with PM < 2.5 μm of diameter (PM2.5) at concentrations of 3, 5 and 10 µg/mg of tissue. The oxidative damage caused by lipid peroxidation of these structures was determined by testing the thiobarbituric acid reactive species (TBA-RS). In addition, we measured the activity of antioxidant enzyme catalase (CAT) and superoxide dismutase (SOD). All PM concentrations were able to damage the cerebellum and hippocampus, strongly enhancing the lipid peroxidation in both structures. PM incubation also decreased the CAT activity of the hippocampus, cerebellum, striatum and olfactory bulb, though it did not generate higher levels of lipid peroxidation in either of the last two structures. PM incubation did n...Continue Reading

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Citations

May 22, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jingliang DongChunying Chen
Nov 19, 2017·International Journal of Environmental Health Research·Jone VenclovienePaulius Dobozinskas
Jul 12, 2019·Neurotoxicity Research·Ada G Rodríguez-CampuzanoArturo Ortega
Jan 9, 2020·Annual Review of Public Health·Michael HendryxJuhua Luo
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Apr 24, 2021·Environmental Science and Pollution Research International·Rosane Bossle BernardiCláudia Ramos Rhoden
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Jul 13, 2021·Frontiers in Cellular Neuroscience·Monika Jankowska-KieltykaIrena Nalepa
Jul 17, 2021·Environmental Science and Pollution Research International·Liying SongJinzhuo Zhao

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