Abstract
Chronic lymphoid leukemia (CLL) is a malignant hematopoietic disorder, the most common of all adult leukemias with a distinctive immunophenotype. It is well established that CLL patients can have autoimmune complications, amongst them autoimmune hemolytic anemia as the most frequent. This study was carried out to determine the frequency of direct Coombs Test positivity in CLL patients and its possible correlation with Rai staging, hematological parameters and biochemical markers. This descriptive cross sectional study was carried at Liaquat National Hospital from January 2011 to June 2013. Sixty untreated patients with B- chronic lymphoid leukemia were enrolled. Complete blood count, direct Coombs test, serum urea, creatinine, uric acid and LDH levels were determined. Data were compiled and analyzed using SPSS version 21. Out of 60 patients, 42(70%) were males and 18(30%) were females. Mean age was 59±9.2 years. Male to female ratio was 2.1: 1. The frequency of direct antiglobulin test (DAT) positivity was found to be 23.3%. The monospecific IgG was positive in 11 patients (18.3%); C3d positivity was evident in 1 patient (1.6%) and 2 patients (3.3%) had dual IgG and C3d positivity. The mean hemoglobin was 10.8±2.4gm/ dl. Signif...Continue Reading
References
Oct 1, 1990·Annals of Internal Medicine·K A FoonR P Gale
Aug 1, 1988·Postgraduate Medical Journal·M LischnerM Shaklai
Jul 1, 1986·Journal of Clinical Pathology·T J HamblinB J Young
Sep 2, 2003·American Journal of Hematology·Mouhammed J KyasaClive S Zent
Jun 15, 2007·Hematology·Neerja AgrawalV P Choudhary
Dec 7, 2007·Blood·Claire DeardenUNKNOWN NCRI CLL Working Group
Jan 25, 2008·Blood·Michael HallekUNKNOWN International Workshop on Chronic Lymphocytic Leukemia
Apr 1, 2008·British Journal of Haematology·Clive S ZentSusan L Slager
May 2, 2008·Blood Reviews·Carol Moreno, Emili Montserrat
Jul 17, 2009·Leukemia & Lymphoma·Wei XuYu-Jie Wu
Jul 14, 2010·Best Practice & Research. Clinical Haematology·Clive S Zent, Neil E Kay
Aug 26, 2010·Blood·Carol MorenoEmili Montserrat
Jan 19, 2011·Haematologica·Kate HodgsonCarol Moreno
Sep 22, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Zahra MozahebMonavar Afzal Aghaee
Jun 19, 2013·Clinical Lymphoma, Myeloma & Leukemia·Francesca RicciMarco Montillo
Jan 8, 2015·Cellular Oncology (Dordrecht)·Mohammad ShahjahaniNajmaldin Saki
Feb 17, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Rozina ZeeshanMuhammad Asif Hameed
Mar 7, 2015·Asian Pacific Journal of Cancer Prevention : APJCP·Rozina ZeeshanSanjana Bhimani