Direct correlation between genome dimerization and recombination efficiency of HIV-1

Microbes and Infection
Jun-Ichi SakuragiTatsuo Shioda

Abstract

More than ten subtypes of Human immunodeficiency virus type 1 (HIV-1) have been identified, and many inter-subtype recombinant viruses have been isolated. The genome of HIV-1 is a single-stranded positive sense RNA, and is always found as dimers in virus particles. Frequent recombination between two genomes during reverse transcription is often observed and thus reasonable to assume that genome dimerization controls viral genomic recombination. Recently, several reports indicated in vitro/in vivo data to support this idea. In the study reported here, in an attempt to show a comprehensive evidence, we compared the efficiency of various inter-subtype dimerization and recombination and detected a near-complete correlation of the two functions. This suggests that genome dimerization controls recombination and plays an important role in promoting the genetic diversity of HIV-1 in general. We also investigated various inter-subtype hetero-dimerization within HIV-1 virions, and found that the dimer initiation site is a major, but not the sole determinant of dimerization (and recombination) efficiency.

References

Jul 1, 1977·The Journal of General Virology·F L GrahamR Nairn
Jan 1, 1990·International Reviews of Immunology·A Aldovini, R A Young
Oct 3, 1999·AIDS Research and Human Retroviruses·N MochizukiM Tatsumi
Mar 14, 2003·Journal of Virology·Jun-Ichi SakuragiTatsuo Shioda
Jun 16, 2005·Proceedings of the National Academy of Sciences of the United States of America·Mario P S ChinWei-Shau Hu
Aug 11, 2005·Infection·B Jülg, F D Goebel
Mar 6, 2007·Virology·Mario P S ChinWei-Shau Hu
Apr 15, 2008·Microbes and Infection·Jun-ichi SakuragiTatsuo Shioda
Dec 17, 2008·Journal of Virology·Jun TakehisaBeatrice H Hahn
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jianbo ChenWei-Shau Hu

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Citations

Feb 14, 2012·Nucleic Acids Research·Jun-ichi SakuragiHironori Sato
Aug 19, 2015·The Journal of General Virology·Sayuri SakuragiJun-Ichi Sakuragi
Feb 25, 2014·Journal of Biomolecular Structure & Dynamics·Irina N KolomietsDmytro M Hovorun
Jan 31, 2012·Intervirology·Saleta Sierra-Aragón, Hauke Walter
Nov 12, 2016·Retrovirology·Sayuri SakuragiJun-Ichi Sakuragi
Apr 4, 2021·International Journal of Molecular Sciences·Sayuri SakuragiJun-Ichi Sakuragi

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