Direct correlation between serum homocysteine level and insulin resistance index in patients with subclinical hypothyroidism: Does subclinical hypothyroidism increase the risk of diabetes and cardio vascular disease together?

Diabetes & Metabolic Syndrome
Anahita EbrahimpourZoleikha Moazezi

Abstract

Subclinical hypothyroidism known as mild thyroid disorder without significant sign and symptoms. The correlation between subclinical hypothyroidism and some of cardiovascular disease risk factors such as serum lipids, homocysteine levels and also insulin resistance index is not well established and the current study was conducted to clarify this issue. Seventy four patients with mild elevation in levels of thyroid stimulating hormone (TSH) along with normal levels of T3 and T4 were selected as patients group and 74 age and sex matched individuals were selected as healthy control group. Serum insulin, triglyceride, glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol and homocysteine levels were measured. Obtained data compared between groups with independent sample t-test. For evaluation of the correlation between mentioned parameters Pearson correlation coefficient method was used. Serum levels of LDL-C and total cholesterol significantly increased in SCH group compared to healthy control group. Homeostatic Model Assessment of Insulin Resistance (HOM-IR) and serum homocysteine level significantly elevated in patients with SCH compared to control group. There was a significant direct correlation between HOM-IR and serum...Continue Reading

Citations

Jul 7, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Shou-Fa ZhangYa-Qing Zhang
Jul 10, 2019·JAMA : the Journal of the American Medical Association·Bernadette BiondiDavid S Cooper
Jan 8, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Xiumin LiuBo Li
Aug 11, 2021·Experimental and Therapeutic Medicine·Roxana Adriana StoicaConstantin Ionescu-Tîrgoviște

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