Direct demonstration of lipid sequestration as a mechanism by which rosiglitazone prevents fatty-acid-induced insulin resistance in the rat: comparison with metformin

Diabetologia
J YeEdward W Kraegen

Abstract

Thiazolidinediones can enhance clearance of whole-body non-esterified fatty acids and protect against the insulin resistance that develops during an acute lipid load. The present study used [(3)H]-R-bromopalmitate to compare the effects of the thiazolidinedione, rosiglitazone, and the biguanide, metformin, on insulin action and the tissue-specific fate of non-esterified fatty acids in rats during lipid infusion. Normal rats were treated with rosiglitazone or metformin for 7 days. Triglyceride/heparin (to elevate non-esterified fatty acids) or glycerol (control) were then infused for 5 h, with a hyperinsulinaemic clamp being performed between the 3rd and 5th hours. Rosiglitazone and metformin prevented fatty-acid-induced insulin resistance (reduced clamp glucose infusion rate). Both drugs improved insulin-mediated suppression of hepatic glucose output but only rosiglitazone enhanced systemic non-esterified fatty acid clearance (plateau plasma non-esterified fatty acids reduced by 40%). Despite this decrease in plateau plasma non-esterified fatty acids, rosiglitazone increased fatty acid uptake (two-fold) into adipose tissue and reduced fatty acid uptake into liver (by 40%) and muscle (by 30%), as well as reducing liver long-chai...Continue Reading

References

Mar 7, 1998·The Journal of Biological Chemistry·M ShimabukuroR H Unger
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·M HigaR H Unger
Mar 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·Y T ZhouR H Unger
May 16, 2001·Current Opinion in Lipidology·N S Shachter
Oct 17, 2001·The Journal of Clinical Investigation·G ZhouD E Moller
Jan 5, 2002·Journal of the Royal Society of Medicine·Aziz Sheikh
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
Sep 21, 2002·Diabetologia·K N Frayn
Jan 28, 2003·Biochemical Society Transactions·B E KempL A Witters
Jan 31, 2003·American Journal of Physiology. Endocrinology and Metabolism·Ji-Ming YeEdward W Kraegen
Jun 13, 2003·Nature·Toshimasa YamauchiTakashi Kadowaki
Aug 1, 1959·Canadian Journal of Biochemistry and Physiology·E G BLIGH, W J DYER
Sep 23, 2003·Endocrinology·Neil B RudermanEdward W Kraegen
Nov 20, 2003·Nature Medicine·Andrea L HevenerJerrold Olefsky

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Citations

May 30, 2008·The British Journal of Nutrition·Arrate LasaMaría Puy Portillo
May 27, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jose M Arbones-MainarNobuyo Maeda
Feb 2, 2006·Diabetes, Obesity & Metabolism·H J KimB S Cha
Jun 17, 2006·Diabetes, Obesity & Metabolism·Kathleen L Wyne
Apr 12, 2011·Diabetes, Obesity & Metabolism·P MayerA Pfeifer
Jun 4, 2008·Annual Review of Biochemistry·Peter Tontonoz, Bruce M Spiegelman
May 14, 2009·American Journal of Physiology. Endocrinology and Metabolism·Dong-Ho HanJohn O Holloszy
Jul 12, 2005·The Journal of Clinical Investigation·Patricia C ChuiMitchell A Lazar
Mar 3, 2006·The Journal of Clinical Investigation·Robert K SempleStephen O'Rahilly
Oct 30, 2012·Diabetology & Metabolic Syndrome·Bodo HaasNiels Eckstein
Nov 6, 2007·Biological & Pharmaceutical Bulletin·So Hui KimChang-Kee Hyun
Oct 7, 2011·The Libyan Journal of Medicine·Yousef A Taher, Abas Hj Hussin
Jul 19, 2006·Current Medical Research and Opinion·Lawrence A Leiter
Feb 24, 2016·Trends in Pharmacological Sciences·Nigel TurnerJi-Ming Ye
Jan 30, 2016·Trends in Cell Biology·Sona KangEvan D Rosen
May 20, 2006·The Journal of Physiology·Marie DavalPascal Ferré
Dec 19, 2012·Journal of Diabetes and Its Complications·Nikhil V Dhurandhar
Sep 22, 2009·Metabolism: Clinical and Experimental·Paulina SkrobukHeikki A Koistinen
Jan 15, 2008·Physiology & Behavior·M C E Bragt, H E Popeijus
Dec 25, 2007·Advances in Enzyme Regulation·Nadir M MaraldiFrancesco A Manzoli
Apr 21, 2007·Metabolism: Clinical and Experimental·Hae Jin KimBong Soo Cha
Sep 23, 2014·Cell Metabolism·Raymond E SoccioMitchell A Lazar
Apr 4, 2016·Trends in Molecular Medicine·Brian FinanMatthias H Tschöp
Oct 6, 2015·Trends in Pharmacological Sciences·Sascha Sauer
Jun 30, 2012·Journal of Ethnopharmacology·Qian QianTao Wang
Aug 18, 2009·Biochimica Et Biophysica Acta·Isaac G OnyangoRussell H Swerdlow

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