Direct dose mapping versus energy/mass transfer mapping for 4D dose accumulation: fundamental differences and dosimetric consequences

Physics in Medicine and Biology
Haisen S LiIndrin J Chetty

Abstract

The direct dose mapping (DDM) and energy/mass transfer (EMT) mapping are two essential algorithms for accumulating the dose from different anatomic phases to the reference phase when there is organ motion or tumor/tissue deformation during the delivery of radiation therapy. DDM is based on interpolation of the dose values from one dose grid to another and thus lacks rigor in defining the dose when there are multiple dose values mapped to one dose voxel in the reference phase due to tissue/tumor deformation. On the other hand, EMT counts the total energy and mass transferred to each voxel in the reference phase and calculates the dose by dividing the energy by mass. Therefore it is based on fundamentally sound physics principles. In this study, we implemented the two algorithms and integrated them within the Eclipse treatment planning system. We then compared the clinical dosimetric difference between the two algorithms for ten lung cancer patients receiving stereotactic radiosurgery treatment, by accumulating the delivered dose to the end-of-exhale (EE) phase. Specifically, the respiratory period was divided into ten phases and the dose to each phase was calculated and mapped to the EE phase and then accumulated. The displaceme...Continue Reading

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Citations

Nov 4, 2016·Medical Physics·Cornelis Ph KamerlingUwe Oelfke
Jan 20, 2017·Medical Physics·Sara GholampourkashiEmily Heath
Feb 28, 2018·Scientific Reports·Peter ZiegenheinUwe Oelfke
Oct 9, 2014·Physics in Medicine and Biology·Stefan MilzWolfgang Ullrich
Jan 1, 2017·International Journal of Particle Therapy·Kim Melanie KrausFlorian Sterzing
Jan 21, 2021·International Journal of Radiation Oncology, Biology, Physics·Carri K Glide-HurstEvan Wuthrick

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