Direct effect of carbon monoxide on hexobarbital metabolism in the isolated perfused liver in the absence of hemoglobin

Journal of Toxicology and Environmental Health
T TakanoR Okeda

Abstract

The interaction of carbon monoxide (CO) with cytochrome P-450 associated with hexobarbital metabolism was observed in hemoglobin-free perfused rat liver by using a scanning reflectance spectrophotometer. The evidence obtained showed that CO bound to the substrate complexed cytochrome P-450 and, at a CO/O2 ratio of over 0.1 in the perfusate, inhibited the hexobarbital metabolism estimated from the hexobarbital uptake, and oxygen consumption. Although the oxygen supply to the liver cell was one of the major limiting factors during CO hypoxia, CO binding to cytochrome P-450 significantly enhanced the suppression of hexobarbital oxidation caused by hypoxic hypoxia.

References

Aug 27, 1977·Lancet·G S Venables
Oct 5, 1970·Annals of the New York Academy of Sciences·R W EstabrookA G Hildebrandt
Oct 1, 1973·Journal of Applied Physiology·M R Montgomery, R J Rubin
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Citations

Mar 1, 2007·Environmental Health and Preventive Medicine·Takehito Takano
Oct 1, 1988·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·T TakanoK Nakata
Nov 1, 1995·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M WatanabeK Nakamura
May 15, 2002·Antioxidants & Redox Signaling·Claude A Piantadosi
Aug 19, 2007·American Journal of Respiratory and Critical Care Medicine·Ramona O HopkinsJohn Carlquist
Sep 14, 1999·The American Journal of Physiology·D G le CouteurA J McLean

Related Concepts

Anoxemia
Carbon Monoxide
High Pressure Liquid Chromatography Procedure
Cytochrome P-450 Oxygenase
Fluorometry
Evipan
Liver
NADH
Oxygen Consumption
August Rats

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