PMID: 2507374Jul 1, 1989Paper

Direct effects of estrogen on c-fos and c-myc protooncogene expression and cellular proliferation in human breast cancer cells

Molecular and Cellular Endocrinology
B van der BurgE J van Zoelen

Abstract

Estrogen induces DNA synthesis to a lesser degree, but with similar kinetics compared to insulin-like growth factors when added to quiescent MCF7 human breast cancer cells. Moreover, this steroid rapidly induces expression of the growth-related c-fos and c-myc protooncogenes. The induction was shown to be a direct effect, independent of protein synthesis. These results demonstrate that no growth factor production is involved in estrogen-induced protooncogene expression, and that these direct effects on gene expression may be an important step in estrogen-induced mitogenesis.

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Citations

Jan 1, 1996·Breast Cancer Research and Treatment·M BoydS A Bartow
Oct 1, 1991·Steroids·S M HyderD S Loose-Mitchell
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Jun 1, 1994·Molecular and Cellular Endocrinology·E KalkhovenB van der Burg
Aug 11, 1995·Molecular and Cellular Endocrinology·B van der BurgP T van der Saag
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Jan 1, 1991·The Journal of Steroid Biochemistry and Molecular Biology·L J Murphy
Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·E M BernsJ G Klijn
Sep 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·B van der BurgS W de Laat
Jun 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·B van der BurgS W de Laat
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