PMID: 8614244Mar 3, 1995Paper

Direct effects of fentanyl on canine coronary artery rings

Life Sciences
R P IntronaJ K Pruett

Abstract

The potent opioid fentanyl, is commonly used as a general anesthetic for coronary artery bypass surgery. Experiments were designed to determine the direct effects of fentanyl on unstimulated coronary artery tissue. Isolated, endothelium denuded canine epicardial rings were suspended in physiologic tissue baths. Changes in tension were measured as the concentration of fentanyl was increased. Fentanyl caused increases in ring tension at concentrations of 10(-6)M-10(-4)M, then caused a decrease in tension at 10(-3) M. Calcium channel blockade by 10(-7)M nifedipine abolished all increases in contractile responses to fentanyl and prevented the relaxation in tension produced by fentanyl. The fentanyl dose-response curve was unchanged by opioid receptor blockade with 10(-6)M naloxone and by alpha and beta adrenoceptor blockade produced by 10(-6)M prazosin and 10(-6)M propranolol. Muscarinic blockade with 10(-6)M atropine and cyclooxygenase inhibition by 10(-6)M indomethacin attenuated the constrictor response to fentanyl. The opioids alfentanil, sufentanil, morphine, and naloxone all produced a dose-response similar to fentanyl that varied only in amplitude. These findings indicate that increasing concentration of the anesthetic opioi...Continue Reading

References

Jan 1, 1991·Journal of Cardiovascular Pharmacology·L A KindmanR Ginsburg
May 1, 1985·Anesthesiology·B A Dodson, K W Miller
Jun 23, 1994·The New England Journal of Medicine·N G UrenP G Camici

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Citations

Jun 9, 2005·Vascular Pharmacology·Sadi S OzdemOguz K Baskurt
Feb 6, 2003·Autonomic & Autacoid Pharmacology·N SahinG Sadan
Nov 24, 2006·American Journal of Therapeutics·Alan D KayeShane Huffman
Apr 18, 2009·British Journal of Clinical Pharmacology·Reza AfshariD Nicholas Bateman
Aug 16, 2001·Critical Reviews in Toxicology·E J Calabrese, L A Baldwin
May 23, 2003·Anesthesia and Analgesia·Randa K NoseirThomas J Ebert
Jun 19, 2001·American Journal of Physiology. Heart and Circulatory Physiology·T J StaughtonP D Weinberg

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