Direct effects of nitric oxide on histamine release from rat enterochromaffin-like cells

European Journal of Pharmacology
Naozumi ShibataMorikazu Onji

Abstract

The direct effects of nitric oxide (NO) on enterochromaffin-like (ECL) cells have not yet been demonstrated. In this study we investigated the direct effects of NO donors on rat ECL cells. The NO donor, NOR3 (10 and 100 microM), decreased gastrin-induced histamine release. 100 microM NOR3 increased cGMP levels and reduced gastrin-induced calcium influx. ODQ, an inhibitor of guanylate cyclase, completely blocked NOR3-induced inhibition of histamine release. These results suggest that NO inhibits gastric acid secretion via suppression of gastrin-induced histamine release through a pathway in which NO activates guanylate cyclase, in addition to increasing cGMP levels and reducing gastrin-induced calcium influx. The use of NO as a new type of gastric acid inhibitor that decreases histamine levels in the stomach would be beneficial as increased histamine levels resulting from use of a histamine H2 receptor antagonist or proton pump inhibitor have various effects on tumors and immunological functions.

References

Apr 1, 1992·The American Journal of Physiology·T R BilliarS A Murray
Dec 1, 1992·Gastroenterology·M E Stark, J H Szurszewski
Nov 1, 1995·Free Radical Research·S FukuyamaH Sakurai
Aug 1, 1993·Gastroenterology·C PrinzG Sachs
Jan 1, 1994·Digestion·R HåkansonH Mattsson
Mar 6, 1995·European Journal of Pharmacology·Y KitaK Yoshida
Sep 1, 1994·European Journal of Pharmacology·D BarrachinaJ V Esplugues
Jan 1, 1995·Physiological Reviews·S J Hersey, G Sachs
Apr 22, 1994·The Journal of Comparative Neurology·R De GiorgioC Sternini
May 12, 1994·European Journal of Pharmacology·Y KitaK Yoshida
Sep 30, 1993·Biochemical and Biophysical Research Communications·J F BrownB J Whittle
Jun 1, 1993·Pharmacology & Toxicology·E P Brass, W H Vetter
Feb 20, 1996·Proceedings of the National Academy of Sciences of the United States of America·M A MoroS Moncada
Jun 1, 1996·Clinical and Experimental Pharmacology & Physiology·P F SheehanD H Barkla
Nov 24, 1999·The American Journal of Physiology·C PrinzM Gratzl
Jul 11, 2000·Seminars in Cancer Biology·E BoltonD L Morris
Jun 16, 2001·European Journal of Pharmacology·K HasebeK Watanabe
Jan 15, 2002·American Journal of Physiology. Cell Physiology·Robert ZannerChristian Prinz
Dec 4, 2003·European Journal of Pharmacology·Tomoyuki YokotaMorikazu Onji

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Citations

Jan 26, 2013·Journal of Molecular Endocrinology·E GrossiniG Vacca
Oct 2, 2007·Current Opinion in Gastroenterology·Mitchell L Schubert
Jan 11, 2013·Physiological Reviews·Sascha Kopic, John P Geibel

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