Direct effects of platelet-activating factor on glomerular capillary permeability

Kidney & Blood Pressure Research
R SharmaV J Savin

Abstract

Platelet-activating factor (PAF) is an important mediator of injury in acute renal failure and glomerulonephritis. Intrarenal infusion of PAF reduces glomerular filtration rate and renal plasma flow and increases glomerular permselectivity via its renal hemodynamic and/or immunologic effects. Direct effects of PAF on glomerular capillary permeability are not known. We studied the direct effects of PAF on mesangial contraction (a measure of filtration area), glomerular capillary hydraulic conductivity (L[p]) and capillary albumin permeability (P[albumin]). Glomeruli were isolated from Sprague-Dawley rats and incubated with or without various concentrations of PAF (10[-9], 10[-7] and 10[-5] M) for up to 5 h at 37 degrees C. Mesangial contraction (percent change in glomerular volume) was assessed from the gradual decrease in volume of glomeruli during 20 min of incubation with PAF. L(p) was calculated from the rate of change in glomerular volume during the 0.1 s of capillary expansion in response to a transcapillary oncotic gradient. P(albumin) was calculated from a change in relative volume of glomeruli in response to an oncotic gradient. Mesangial contraction was maximal after 20 min of incubation and was concentration dependent...Continue Reading

Citations

May 7, 1999·Kidney International·J M López-Novoa
Jul 16, 2004·Metabolism: Clinical and Experimental·Tomohito GohdaYasuhiko Tomino
Jan 15, 2014·Free Radical Biology & Medicine·Calivarathan LatchoumycandaneThomas M McIntyre
Oct 9, 2015·American Journal of Physiology. Renal Physiology·Fan FanRichard J Roman
Jan 15, 2002·Experimental Biology and Medicine·Ram SharmaVirginia J Savin
Apr 27, 2000·American Journal of Physiology. Lung Cellular and Molecular Physiology·C L SpeyerJ L Ram
Nov 5, 2002·The American Journal of Pathology·Eishin YaoitaTadashi Yamamoto
Dec 1, 2001·Journal of the American Society of Nephrology : JASN·Bing LiTakashi Oite

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