Direct effects of quercetin on impaired reactivity of spontaneously hypertensive rat aortae: comparative study with ascorbic acid

Clinical and Experimental Pharmacology & Physiology
M AjayM R Mustafa

Abstract

1. There is a growing interest in the anti-oxidant characteristics and use of flavonoids in the management of cardiovascular diseases. The cardiovascular mechanism of action of these plant derivatives remains controversial. This study compared the effects of the flavonoid quercetin with those of the anti-oxidant vitamin ascorbic acid (vitamin C) on the reactivity of aortic rings from spontaneously hypertensive rats (SHR). 2. The phenylephrine (PE)-induced contractile and the endothelium-dependent and independent relaxant responses of aortic rings from 21 to 22 week old SHR and age-matched normotensive Wistar (WKY) rats were observed in the presence of quercetin or ascorbic acid. All the experiments were performed in the presence of the cyclooxygenase inhibitor, indomethacin (10 micromol/L). 3. The endothelium-dependent and independent relaxations to acetylcholine (ACh) and sodium nitroprusside (SNP), respectively, were significantly lesser in the SHR compared to the WKY tissues whereas the contractile responses to PE were similar in both tissues. Pretreatment of WKY rings with quercetin or ascorbic acid had no effect on the responses to ACh or PE. In the SHR tissues, however, quercetin or ascorbic acid significantly improved th...Continue Reading

References

Feb 24, 1996·BMJ : British Medical Journal·P KnektJ Maatela
Jan 1, 1996·Free Radical Biology & Medicine·Z S Katusic
Jan 1, 1996·Free Radical Biology & Medicine·C A Rice-EvansG Paganga
Jan 8, 1999·American Journal of Hypertension·M J Akpaffiong, A A Taylor
Feb 27, 2001·Current Opinion in Nephrology and Hypertension·C BerryA F Dominiczak
Sep 22, 2001·The American Journal of Clinical Nutrition·R J NijveldtP A van Leeuwen
Jun 13, 2002·Journal of Agricultural and Food Chemistry·Dae-Ok KimChang Yong Lee
Nov 19, 2003·Life Sciences·Machha AjayMohd Rais Mustafa
Jan 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Salvatore CuzzocreaD Salvemini
Sep 15, 2004·American Journal of Hypertension·Bernard Lassègue, Kathy K Griendling
Oct 12, 2004·Journal of Cardiovascular Pharmacology·Roberto Soares de MouraAngela C Resende
Jun 21, 2005·Journal of Cardiovascular Pharmacology·Ajay Machha, Mohd Rais Mustafa

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Citations

Jun 1, 2011·European Journal of Nutrition·Ajay Machha, Alan N Schechter
Mar 6, 2009·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hui WangGuangwei Li
Aug 14, 2012·BMC Complementary and Alternative Medicine·Arif-ullah KhanDharmani Devi Murugan
May 3, 2014·Clinical and Experimental Hypertension : CHE·Munasib KhanAnwarul-Hassan Gilani
Apr 4, 2012·Clinical and Experimental Hypertension : CHE·Munasib KhanAnwarul-Hassan Gilani
Apr 14, 2016·Kidney Research and Clinical Practice·Seok ChoiCheol Ho Yeum
Mar 1, 2008·Nitric Oxide : Biology and Chemistry·Daniella BonaventuraLusiane M Bendhack
Apr 20, 2007·European Journal of Pharmacology·Ajay MachhaMohd Rais Mustafa
Sep 3, 2011·Basic & Clinical Pharmacology & Toxicology·José Couras Silva-FilhoAldeídia P Oliveira
Aug 26, 2009·Fundamental & Clinical Pharmacology·Peyman U ErtuğErgin Singirik
Sep 16, 2006·Journal of Ethnopharmacology·M AjayM R Mustafa
Jun 6, 2009·Nitric Oxide : Biology and Chemistry·Christoph A Schmitt, Verena M Dirsch
Mar 22, 2008·Journal of Cardiovascular Pharmacology·I MackrajS Ramesar
Aug 6, 2009·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Iveta BernatovaSilvia M Arribas
Dec 14, 2011·Experimental Biology and Medicine·Yeh-Siang LauMohd Rais Mustafa
Apr 14, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nadeem IrshadMuhammad Shahid Iqbal
Oct 23, 2010·Journal of Agricultural and Food Chemistry·Aleksandra S KristoDorothy J Klimis-Zacas

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