PMID: 9187996Jun 1, 1997Paper

Direct effects of triiodothyronine on human internal mammary artery and saphenous veins

Journal of Cardiothoracic and Vascular Anesthesia
L J KrasnerC Carlsson

Abstract

Thyroid hormone (3,5,3'-triiodo-L-thyronine is under investigation as a positive inotrope and vasodilator for patients undergoing cardiac surgery. This study determined the direct effects of triiodothyronine on human blood vessels. Prospective, controlled, in vitro study. Laboratory facility in a university teaching hospital. Small excess segments of internal mammary arteries or saphenous veins were obtained from patients undergoing coronary artery bypass surgery. Vessel segments were cut into rings to measure isometric tension development in isolated tissue baths containing Krebs-Ringer bicarbonate solution at 37 degrees C. Rings were prestretched in vitro to resting tensions analogous to mean arterial or central venous pressures in vivo and then constricted with potassium or phenylephrine. Rings were exposed to increasing concentrations of triiodothyronine (4 x 10(-12) to 1 x 10(-4) mol/L) to obtain dose-response curves. High concentrations (> or = 3.3 x 10(-5) mol/L) of trilodothyronine produced dose-dependent relaxation of preconstricted rings. The relaxation was not selective for arteries or veins at arterial resting tensions, and with either potassium or phenylephrine as a vasoconstrictor. Propranolol had little effect on...Continue Reading

References

Aug 1, 1977·The Journal of General Physiology·G DroogmansR Casteels
Dec 1, 1992·Journal of Cardiac Surgery·D R SalterA S Wechsler
Jul 1, 1991·The Annals of Thoracic Surgery·F W HollandR E Clark
Dec 7, 1995·The New England Journal of Medicine·J D KlempererK Krieger
Jul 1, 1995·Acta Anaesthesiologica Scandinavica·J KarlssonC Carlsson
Jul 1, 1993·The Annals of Thoracic Surgery·R E Clark
Jul 1, 1993·The Annals of Thoracic Surgery·K OjamaaI L Klein

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Citations

Oct 28, 2009·Vascular Pharmacology·Maria Luiza M Barreto-ChavesGabriela P Diniz
Dec 19, 2001·Journal of Cardiothoracic and Vascular Anesthesia·W W WendlingC Carlsson
May 3, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Viviane ConraadsChristiaan Vrints
Oct 28, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Omar R FarahJaques Belik
Dec 31, 2020·The Journal of Clinical Hypertension·Stanislovas S JankauskasGaetano Santulli

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