Direct electrophilic monofluoromethylation

Organic Letters
G K Surya PrakashGeorge A Olah

Abstract

Monofluoromethyl derivatives of various nucleophiles have been synthesized using a new electrophilic monofluoromethylating reagent developed. The S-(monofluoromethyl)diarylsulfonium tetrafluoroborate has been shown to be effective for the introduction of an electrophilic monofluoromethyl group into C, S, O, N, and P nucleophiles. This methodology has been expanded for the synthesis of various biologically important compounds.

References

Feb 12, 2000·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·L Zheng, M S Berridge
Oct 24, 2001·The Journal of Organic Chemistry·Jing-Jing YangJean'ne M. Shreeve
Aug 31, 2002·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Ren IwataKazuhiko Yanai
Apr 21, 2007·Organic Letters·G K Surya PrakashGeorge A Olah

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Citations

Oct 30, 2009·Chemical Communications : Chem Comm·Wen-Bo LiuShu-Li You
Dec 22, 2009·Chemical Communications : Chem Comm·Jinbo HuFei Wang
Mar 1, 2017·Journal of the American Chemical Society·Li ShangBo Peng
Jul 14, 2017·The Journal of Organic Chemistry·Yang GengYangjie Wu
Oct 7, 2016·Chemical Communications : Chem Comm·Shi-Meng WangCheng-Pan Zhang
Jan 27, 2019·Chemistry : a European Journal·Janis Veliks, Armands Kazia
Apr 15, 2011·Chemistry : a European Journal·José L García RuanoAscensión Sanz-Tejedor
Jul 23, 2013·Angewandte Chemie·Theresa LiangTobias Ritter
Dec 10, 2013·Chemical Communications : Chem Comm·Anna M RydzikChristopher J Schofield
Feb 29, 2020·Angewandte Chemie·Valerio FasanoVarinder K Aggarwal
Feb 6, 2020·Angewandte Chemie·Marco Reichel, Konstantin Karaghiosoff
Feb 20, 2018·Chemical Communications : Chem Comm·Elodie CarbonnelThomas Poisson
Jan 31, 2020·Organic & Biomolecular Chemistry·Armands KaziaJanis Veliks
Sep 18, 2020·Chemistry : a European Journal·Jonathan DecaensPhilippe Jubault
Jan 28, 2021·The Journal of Organic Chemistry·Arturs SpergaJanis Veliks
Mar 5, 2021·The Journal of Organic Chemistry·Marco ReichelKonstantin Karaghiosoff
Oct 4, 2019·Current Medicinal Chemistry·Yuzhong WangCheng-Pan Zhang
Aug 23, 2019·Organic Letters·Renate MelngaileJanis Veliks
Aug 24, 2019·Organic Letters·Paola Acosta-GuzmánDiego Gamba-Sánchez
Jul 24, 2012·Organic Letters·Eddie YangJohn M Humphrey
Dec 8, 2020·The Journal of Organic Chemistry·Toshitaka OkamuraNaoki Kanoh

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