Direct enantiomeric separation of mianserin and 6-azamianserin derivatives using chiral stationary phases

Journal of Chromatography. a
U SelditzH Wikström

Abstract

The direct enantiomeric separation of mianserin and 6-azamianserin and some of their derivatives, respectively, by means of HPLC using two different chiral selectors was investigated. For the cellulose-based Chiralcel OD column, a strong dependence of the lipophilicity of the compounds tested on the retention behaviour was observed. To some extent, this was also found for the enantiomeric separation on the amylose-based Chiralpak AD column. In some cases a complementary behaviour of these two phases was observed: racemic mixtures that could not be separated by one column could be resolved by the other one.

Citations

Sep 5, 2002·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·J M Mancilla-DíazS E Cruz-Morales
Apr 21, 2010·Journal of Separation Science·Chun LinZiyuan Guo
Feb 9, 2002·Biopharmaceutics & Drug Disposition·G Gübitz, M G Schmid
Dec 7, 2000·Journal of Pharmaceutical and Biomedical Analysis·N Karaşen, S Altinöz

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