Direct enhancement of nitrogen-15 targets at high-field by fast ADAPT-SABRE.

Journal of Magnetic Resonance
Soumya S RoySimon B Duckett

Abstract

Signal Amplification by Reversible Exchange (SABRE) is an attractive nuclear spin hyperpolarization technique capable of huge sensitivity enhancement in nuclear magnetic resonance (NMR) detection. The resonance condition of SABRE hyperpolarization depends on coherent spin mixing, which can be achieved naturally at a low magnetic field. The optimum transfer field to spin-1/2 heteronuclei is technically demanding, as it requires field strengths weaker than the earth's magnetic field for efficient spin mixing. In this paper, we illustrate an approach to achieve strong 15N SABRE hyperpolarization at high magnetic field by a radio frequency (RF) driven coherent transfer mechanism based on alternate pulsing and delay to achieve polarization transfer. The presented scheme is found to be highly robust and much faster than existing related methods, producing ∼3 orders of magnitude 15N signal enhancement within 2 s of RF pulsing.

Citations

Jan 10, 2018·Angewandte Chemie·Peter J Rayner, Simon B Duckett
Jun 20, 2018·The Analyst·Peter M RichardsonMeghan E Halse
Feb 28, 2018·Angewandte Chemie·Jan-Bernd HövenerEduard Y Chekmenev
Nov 6, 2018·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Anand ManoharanSimon B Duckett
Apr 6, 2019·Chemistry : a European Journal·Alexandra SvyatovaIgor V Koptyug
Jan 17, 2020·Magnetic Resonance in Chemistry : MRC·Thomas TennantRyan E Mewis
Apr 16, 2020·Physical Chemistry Chemical Physics : PCCP·Andrey N Pravdivtsev, Jan-Bernd Hövener
Apr 25, 2020·Physical Chemistry Chemical Physics : PCCP·Christian BengsMalcolm H Levitt
May 22, 2018·Chemical Science·Wissam IaliSimon B Duckett
Apr 1, 2019·The Journal of Chemical Physics·Stephan Knecht, Konstantin L Ivanov
Oct 16, 2018·Catalysis Science & Technology·Chin Min WongBarbara A Messerle
Oct 8, 2019·Chemical Science·Peter J RaynerSimon B Duckett
Nov 4, 2020·The Journal of Chemical Physics·Stephan KnechtKonstantin L Ivanov
Mar 20, 2021·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Nikita V ChukanovEduard Y Chekmenev
Feb 13, 2018·The Journal of Physical Chemistry Letters·Soumya S RoySimon B Duckett
Oct 9, 2018·The Journal of Physical Chemistry. a·Andrey N PravdivtsevJan-Bernd Hövener
Jul 11, 2019·The Journal of Physical Chemistry Letters·Nuwandi M AriyasinghaEduard Y Chekmenev

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Methods Mentioned

BETA
NMR

Software Mentioned

LIGHT
ADAPT
SABRE

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