PMID: 9170337May 1, 1997Paper

Direct evidence for central sites of action of zolmitriptan (311C90): an autoradiographic study in cat

Cephalalgia : an International Journal of Headache
P J Goadsby, Y Knight

Abstract

The trigeminovascular system consists of bipolar neurons which innervate pain-sensitive intracranial structures and projecting to neurons in the superficial laminae of the caudal trigeminal nucleus and of the dorsal horns of C1 and C2. The serotonin (5HT1B/D) agonist zolmitriptan (311C90) has been shown to be effective in the treatment of acute attacks of migraine and experimental data suggest that it may have both peripheral and central sites of action. This study sought to further investigate possible central effects of zolmitriptan (311C90) by examining its distribution in the central nervous system. Specific binding of [3H]-zolmitriptan was determined both ex vivo and in vitro in the cat brain. For the ex vivo studies, cats were anaesthetized with halothane and alpha-chloralose (60 mg/kg intraperitoneal). A femoral vein catheter was inserted for injection of the [3H]-zolmitriptan and then 1 h after injection the brain removed. For the in vitro studies fresh frozen brain slices were incubated with labelled and masking concentrations of zolmitriptan. The distribution of [3H]-zolmitriptan was determined using quantitative autoradiographic methods. The in vitro work demonstrated specific binding of [3H]-zolmitriptan in the supe...Continue Reading

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Citations

Jan 29, 2011·Current Pain and Headache Reports·Giorgio Lambru, Manjit Matharu
Jun 28, 2000·Progress in Neurobiology·P J Goadsby
May 19, 2000·Cephalalgia : an International Journal of Headache·G GeraudR Sweet
Jun 17, 2005·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C VollonoG Di Trapani
Dec 11, 2008·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M Schürks, H-C Diener
May 12, 2006·Cephalalgia : an International Journal of Headache·U ArulmaniP R Saxena
Apr 22, 1999·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C DahlofK B Klein
Oct 21, 2011·International Journal of Molecular Imaging·Orjan LindheGunnar Antoni
Jul 6, 2012·Expert Opinion on Drug Metabolism & Toxicology·Luana LionettoPaolo Martelletti
Jan 5, 2002·Expert Opinion on Investigational Drugs·H C Diener, V Limmroth
Jul 5, 2005·Expert Opinion on Investigational Drugs·P E Rolan, G R Martin
Jun 27, 2002·Expert Opinion on Pharmacotherapy·Andrew J Dowson, Bruce Charlesworth
Jan 17, 2012·The Journal of Headache and Pain·Mohammad S AsgharMessoud Ashina
Dec 17, 2009·The Journal of Headache and Pain·Peer Carsten Tfelt-Hansen
Dec 7, 2016·Pharmacology & Therapeutics·Simon AkermanPhilip R Holland
Feb 23, 2013·Cephalalgia : an International Journal of Headache·Katarina VarnäsStephen Kanes
Nov 14, 1997·Cephalalgia : an International Journal of Headache·J PascualA Pazos
Feb 11, 2000·Cephalalgia : an International Journal of Headache·K I RoonJ G van Dijk
Jul 4, 2018·Cephalalgia : an International Journal of Headache·Marta Vila-PueyoSimon Akerman
Oct 9, 2002·Pharmazie in unserer Zeit·Hans-Christoph Diener
Aug 1, 1997·Cephalalgia : an International Journal of Headache·L L van de VenP J Koehler
Jan 4, 2006·CNS Drug Reviews·Geoffrey A Lambert
Jun 27, 2006·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies· P S Sándor
Aug 21, 2013·Expert Review of Neurotherapeutics·Simon Akerman, Marcela Romero-Reyes
Sep 28, 1999·Current Opinion in Neurology·H C Diener, V Limmroth
May 23, 2002·Brain : a Journal of Neurology·P J GoadsbyH E Connor
Feb 10, 2017·Physiological Reviews·Peter J GoadsbySimon Akerman
Dec 17, 1997·Cephalalgia : an International Journal of Headache·R Dixon, A Warrander

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