Direct evidence for nitric oxide synthase in vagal afferents to the nucleus tractus solitarii

Neuroscience
L H LinW T Talman

Abstract

The anatomical relationship between vagal afferents and brain nitric oxide synthase containing terminals in the nucleus tractus solitarii was studied by means of anterograde tracing combined with immunocytochemistry and immuno-electron microscopy. Biotinylated dextran amine was injected into the nodose ganglion with a glass micropipette. Four to eight days following the injection, regions of the nucleus tractus solitarii containing biotinylated dextran amine-labelled vagal afferents and those containing nitric oxide synthase-immunopositive terminals were congruent. Many neurons exhibiting nitric oxide synthase immunoreactivity were found within the biotinylated dextran amine-containing terminal field. However dense labeling of terminals with biotinylated dextran amine precluded determination if the terminals were nitric oxide synthase-immunoreactive. Therefore, we combined degeneration of vagal afferents after removal of one nodose ganglion with nitric oxide synthase immuno-electron microscopy. Axon terminals that possessed characteristic vesicle clusters and were partially or completely engulfed by glial processes were identified as degenerating vagal afferents. Degenerating axon terminals comprised 38% of the total axon termi...Continue Reading

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Citations

Sep 25, 2009·Cellular and Molecular Neurobiology·L H LinW T Talman
Apr 12, 2005·Journal of Chemical Neuroanatomy·L H Lin, W T Talman
Jul 17, 1999·Brain Research. Brain Research Reviews·T L Krukoff
Nov 26, 2002·Trends in Neurosciences·Julian F R PatonDavid J Paterson
Dec 19, 2000·Journal of Chemical Neuroanatomy·F O EstevesT F Batten
Oct 31, 2002·Journal of Chemical Neuroanatomy·Li-Hsien Lin, William T Talman
Sep 21, 2001·British Journal of Pharmacology·E QuintanaM D Barrachina
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Claire E SearsBarbara Casadei
Apr 15, 2011·Clinical and Experimental Pharmacology & Physiology·Colleen J ThomasRobyn L Woods
Apr 28, 2005·Journal of Gastroenterology and Hepatology·Alicia S Smith, Scott D Smid
Apr 25, 2009·Pediatric Research·Avnesh S Thakor, Dino A Giussani
May 8, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yoshitaka HirookaAkira Takeshita
Dec 22, 1999·The Japanese Journal of Physiology·M MaedaM Nakai
Mar 22, 2014·Physiology & Behavior·Guillaume de Lartigue
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Sep 26, 2009·Journal of Chemical Neuroanatomy·Li-Hsien Lin
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Mar 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Deoclecio A ChiancaWilliam T Talman
Feb 26, 2004·Hypertension·William T Talman, Deidre Nitschke Dragon
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Dec 31, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ana Carolina Rodrigues Dias, Eduardo Colombari
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Aug 14, 2020·Journal of Anatomy·Ieva NavickaiteDainius H Pauza

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