Direct evidence for the involvement of capsular polysaccharide in the immunoprotective activity of Klebsiella pneumoniae ribosomal preparations.

Infection and Immunity
M RiottotH Jouin

Abstract

Previous work has demonstrated the capsular serotypic specificity of the protection conferred on mice by Klebsiella pneumoniae ribosomal preparations. The data in these studies support the hypothesis that capsular polysaccharide plays at least some role in the specificity of the protection conferred by ribosomal preparations. In this investigation, the presence of capsular polysaccharide and lipopolysaccharide in K. pneumoniae ribosomal preparations was demonstrated by using immunodiffusion tests. Lipopolysaccharide content was determined for mice treated with actinomycin D. The serotype of O antigen did not play a role in the orientation of the specificity of the protection. The possibility that lipopolysaccharide might act as an adjuvant was not unlikely since the ribosomal preparations which contained the greatest amounts of lipopolysaccharide appeared to be the most immunoprotective preparations. Ribosomal preparations extracted from a noncapsulated mutant of K. pneumoniae did not protect mice. This finding suggested that capsular polysaccharide might play a role in the immunoprotective activity of ribosomes. This hypothesis was tested by using K. pneumoniae K2 bacteriophage-associated-glycanase, which specifically hydrolyz...Continue Reading

References

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Citations

Oct 1, 1984·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·D RobertH Wigzell
Dec 1, 1983·European Journal of Clinical Microbiology·S J Cryz
Oct 1, 1984·The Journal of Hygiene·E A Roe, R J Jones
Jan 1, 1984·Antonie van Leeuwenhoek·R GonggrijpC P van Boven
Feb 1, 1989·Infection and Immunity·X NassifP J Sansonetti
Nov 1, 1986·Infection and Immunity·A RobertJ M Fournier
Nov 1, 1986·Infection and Immunity·S J CryzR Germanier
Apr 1, 1986·Journal of Clinical Microbiology·S J CryzR Germanier

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